Student100 said:
you have to make assumptions about the fluid to make it inertial.
I'm not sure I understand your point here, but I'm going to guess that you're thinking that if a fluid is not a Newtonian fluid, then it doesn't follow Newtonian physics, which isn't true. A Newtonian fluid is a fluid in which the viscous stresses arising from its flow, at every point, are linearly proportional to the local strain rate. It's a idealization of viscosity, not about Newton's laws of physics. Wiki article
http://en.wikipedia.org/wiki/Newtonian_fluid
Regardless of viscous effects, in an inertial frame of reference, then all fluids would be "inertial". A force exerted onto the air, results in a change in pressure and/or temperature and/or acceleration, and the reaction follows Newton's laws of physics.
Getting back to the original posters question, a change in pressure coexists with a change in density. Wiki article:
http://en.wikipedia.org/wiki/Compressibility_factor#Compressibility_of_air
In the case of a wing, a density differential coexists with the pressure differential, but it's the net pressure differential on a wing that corresponds to lift and drag forces exerted by the air onto the wing. For level flight, you can calculate the net pressure differential by the wing loading divided by the wing area.
http://en.wikipedia.org/wiki/Wing_loading
Take the example of a large commercial aircraft, the MD-11F, at 173 lbs / ft^2 wing loading, this is equal to about 1.2 psi (lbs / in^2) net pressure differential. Say this is distributed as +0.4 psi below the wing and -0.8 psi above. At near sea level where ambient pressure is about 14.7 psi, these differences are relatively small: +0.4/14.7, -0.8/14.7. At 35,000 feet, ambient pressure is only 3.2 psi, so the relative differences in pressure (and density) are greater, but the net pressure differential is the same. At higher altitudes, due to the lower density of the air, a greater speed and/or greater angle of attack is needed to maintain level flight.