Radioactively labeled compounds unsuitable?

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Certain radioactively labeled compounds, like 32 P-labeled ATP, are unsuitable for whole cell studies because they fail to penetrate cell membranes. The presence of a radioactive isotope does not alter the chemical properties of a molecule, meaning that if a compound cannot enter cells in its non-labeled form, it will not do so when labeled. This raises questions about the accuracy of claims regarding the compound's cellular entry. The discussion emphasizes the importance of understanding the inherent properties of compounds, regardless of labeling, to ensure accurate experimental design and interpretation in cellular studies.
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Some radioactively labeled compounds (such as 32 P-labeled ATP) are not suitable for studies with whole cells because they do not enter cells. Why? The presence of a radioactive isotope does not change the chemical properties of a molecule.
 
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hivesaeed4 said:
Some radioactively labeled compounds (such as 32 P-labeled ATP) are not suitable for studies with whole cells because they do not enter cells. Why? The presence of a radioactive isotope does not change the chemical properties of a molecule.
As you said, the isotope does not change the chemical properties, so either this compound does not enter whole cells at all (regardless of whether it is labeled or not), or your information that it doesn't enter whole cells is wrong. Why do you think this?
 

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