Rh Sensitization: Mother Rh+ve & Child Rh-ve

  • Thread starter Thread starter Suraj M
  • Start date Start date
Click For Summary
SUMMARY

The discussion centers on Rh sensitization, specifically the implications when a mother is Rh-positive (Rh+) and the child is Rh-negative (Rh-), and vice versa. It is established that Rh antibodies can be transmitted from the mother to the baby through the placenta, which is critical in cases of erythroblastosis fetalis. The risk of sensitization primarily occurs during childbirth if there is a mixing of maternal and fetal blood, particularly in cases of microhemorrhages. Once Rh antibodies are produced in an Rh-negative individual, they persist indefinitely.

PREREQUISITES
  • Understanding of Rh factor and blood types
  • Knowledge of erythroblastosis fetalis
  • Familiarity with maternal-fetal blood interactions
  • Basic concepts of immunology related to antibody production
NEXT STEPS
  • Research the mechanisms of erythroblastosis fetalis and its prevention
  • Study the role of Rh immunoglobulin (RhoGAM) in pregnancy
  • Learn about maternal-fetal blood transfusion risks
  • Investigate the effects of microhemorrhages during childbirth
USEFUL FOR

Medical students, obstetricians, hematologists, and anyone involved in prenatal care or blood transfusion practices.

Suraj M
Gold Member
Messages
596
Reaction score
39
A problem arises when the mother is Rh-ve and the child is Rh+ve ,
consider a mother Rh+ve and the child Rh-ve, after birth, if the child is given Rh+ve blood, will the baby just get sensitized or will a reaction take place in the first transfusion itself as the baby was sensitized in the womb itself?
Also when an Rh-ve individual gets sensitized, how long to the Rh antibodies last?
 
Biology news on Phys.org
Rh antibodies, once produced last forever.

A baby only has access to the mom through placenta, so, there is no risk because the placenta only has baby's blood. The only minute circumstance that it could happen is if the baby is injured during the birth process and has an open wound that could be exposed to mom's blood. Even then it would be unlikely.
 
Is the probability of loosing the second baby the same, if the mother is Rh-ve and baby is Rh+ve ... because for that to happen the blood of the mother and baby should mix too, but i have heard that antibodies can be transmitted from the mother to the baby(through the placenta), but not all antibodies, is Rh antibody, one of them?
Thanks for all your replies(not just here), physics student20 :smile:
 
Rh antibodies don't get transmitted from the mother to the baby through placenta if what I feel..
You are welcome :smile:
 
PhyStudent20 said:
Rh antibodies don't get transmitted from the mother to the baby through placenta if what I feel..
actually Rh antibodies do get transmitted from the mother to the baby, that is the basis for erythroblastosis fetalis, it does happen, through the placenta.
But if the mother has Rh antigen and the baby Rh-ve , will the baby get sensitized?
PhyStudent20 said:
Even then it would be unlikely.
microhemorrhages are quite common..but do the Rh antigen(RBC) of the mother enter into the blood stream of the baby or not?
 

Similar threads

  • · Replies 2 ·
Replies
2
Views
3K
Replies
11
Views
2K
Replies
2
Views
3K
  • · Replies 3 ·
Replies
3
Views
4K
  • · Replies 2 ·
Replies
2
Views
15K
  • · Replies 3 ·
Replies
3
Views
3K
  • · Replies 7 ·
Replies
7
Views
5K
  • · Replies 4 ·
Replies
4
Views
2K
Replies
12
Views
5K
Replies
23
Views
7K