Is TMEM108 Effective for Treating Schizophrenia in Humans?

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SUMMARY

TMEM108 has been identified as a significant gene associated with schizophrenia, particularly in its role in neuronal communication. Research indicates that reducing the expression of TMEM108 protein leads to fewer and smaller dendritic spines, which are crucial for neuron communication, as reported by neuroscientist Dr. Lin Mei. While current studies focus on mice, the findings suggest potential applicability to human treatments for schizophrenia. Further exploration is needed to determine the effectiveness of TMEM108-based therapies in humans.

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  • Understanding of genetic mutations and their impact on neurological disorders
  • Familiarity with neuronal communication and synaptic structure
  • Knowledge of schizophrenia and its biological underpinnings
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  • Research the role of TMEM108 in neuronal development and its implications for schizophrenia treatment
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  • Investigate other genetic factors contributing to schizophrenia beyond TMEM108
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Neuroscientists, psychiatrists, genetic researchers, and anyone interested in the genetic basis of schizophrenia and potential therapeutic approaches.

wolram
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I have found this article about schizophrenia, It talk's about TMEM working on mice, I wonder if there is similar
treatment for humans.
https://www.sciencedaily.com/releases/2017/01/170118163751.htmMutations in a gene that should enable memories and a sense of direction instead can result in imprecise communication between neurons that contributes to symptoms of schizophrenia, scientists report.

They found that dramatically reducing the amount of protein expressed by TMEM108, a gene already associated with schizophrenia, results in fewer, smaller spines, which work like communication fingers for neurons, said neuroscientist Dr. Lin Mei.
 
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