Simple Question: Units and volume of DNA - Can't get formula correct?

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Homework Help Overview

The discussion revolves around calculating the average volume occupied by a DNA molecule, given its density and molecular weight. The subject area includes concepts from chemistry and molecular biology, particularly focusing on the relationships between mass, volume, and density.

Discussion Character

  • Exploratory, Conceptual clarification, Mathematical reasoning

Approaches and Questions Raised

  • Participants discuss the formula for volume (V = mass/density) and express confusion regarding unit conversions and the implications of molecular weight in the context of calculating volume for a single molecule. Some participants question the validity of their calculations and seek clarification on the steps involved.

Discussion Status

There is ongoing exploration of the problem with various participants offering insights and questioning assumptions about unit conversions and the application of the formula. Some guidance has been provided regarding the standard approach to the calculation, but no consensus has been reached on the final answer.

Contextual Notes

Participants are grappling with the implications of molecular weight and density, particularly in relation to the volume of a single DNA molecule. There is acknowledgment of the large size of DNA molecules compared to typical molecules, which influences their calculations.

nukeman
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Homework Statement



Deoxyribonucleic acid (DNA) is thought to be the chemical compound
responsible for the process of heredity. A sample of DNA was found to have
density 1.10 g/cm3 and its molecular weight was estimated to be
3.04 × 108 g. What is the average volume occupied by one DNA molecule?

Homework Equations


The Attempt at a Solution



I am stuck here. I know V = mass/density

Would I go something like:

3.04 x 10^8 g per mol x (1 mol / 6.022x10^23 molecules) x ( 1 cm^3 / 1.10 g)

No that's not right...dammit

Any help would be great. I know its a simple question, but I need to know exactly how to get the answer.

Thanks all!
 
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Ignore.
 
Last edited:
tms said:
You know exactly how to get the answer: v = m / \rho. What have moles got to do with it?

I thought the correct units for molecular weight is g/mol, and since we are finding the volume of one DNA molecule, I thought I had to do a few conversion factors.
 
tms said:
Ignore.

If I do it that way 3.04 x 10^8 / 1.1 I get... 2.76364 x 10^8 cm^3

which is impossible for just one DNA molecule to occupy that space.
 
nukeman said:

Homework Statement



Deoxyribonucleic acid (DNA) is thought to be the chemical compound
responsible for the process of heredity. A sample of DNA was found to have
density 1.10 g/cm3 and its molecular weight was estimated to be
3.04 × 108 g. What is the average volume occupied by one DNA molecule?


Homework Equations





The Attempt at a Solution



I am stuck here. I know V = mass/density

Would I go something like:

3.04 x 10^8 g per mol x (1 mol / 6.022x10^23 molecules) x ( 1 cm^3 / 1.10 g)

No that's not right...dammit

Any help would be great. I know its a simple question, but I need to know exactly how to get the answer.

Thanks all!

Your method looks okay. Why do think it's not right? Are having difficulty with the unit conversions for grams or cubic centimeters?
 
The molecular weight defines how much mass of something is in a mole, i.e. 6.02(10^23) molecules. You need to normalize the volume to one molecule. Your answer should be correct. Just make sure you put your answer in the units that the answer called for.
 
nukeman said:
I thought the correct units for molecular weight is g/mol, and since we are finding the volume of one DNA molecule, I thought I had to do a few conversion factors.
Forget what I said; I was answering the wrong question.
 
gneill said:
Your method looks okay. Why do think it's not right? Are having difficulty with the unit conversions for grams or cubic centimeters?

Is there a better way to do this. Can you maybe explain?

When you look at this question, what steps are you thinking to do?

Yes, having little issue with last part (1 cm^3 / 1.10g)

So, when I see something like 1.10g/cm^3, if I want to get rid of the g, i would just go...1cm^3 / 1.10 g

Slightly confused :(
 
nukeman said:
If I do it that way 3.04 x 10^8 / 1.1 I get... 2.76364 x 10^8 cm^3

which is impossible for just one DNA molecule to occupy that space.
DNA molecules are huge (although not that huge; I didn't realize you were still looking at my first stupid answer). Compare its molecular weight with that of a more typical molecule.
 
Last edited:
  • #10
tms said:
DNA molecules are huge (although not that huge; I didn't realize you were still looking at my first stupid answer). Compare its molecular weight with that of a more typical molecule.

lol, yea its true. They are pretty big.
 
  • #11
nukeman said:
Is there a better way to do this. Can you maybe explain?
The method that you used is the standard approach, so no need to tinker there.
When you look at this question, what steps are you thinking to do?
Same as you did!
Yes, having little issue with last part (1 cm^3 / 1.10g)

So, when I see something like 1.10g/cm^3, if I want to get rid of the g, i would just go...1cm^3 / 1.10 g

Slightly confused :(
The grams will cancel with another grams earlier in the expression chain. In fact the first item in the chain was the molecular weight given as grams/mol. So the grams in its numerator cancel the grams in the denominator of the density, even though they are separated by other links in the calculation chain.
 
  • #12
Great, thanks. Much better understanding now!
 

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