Skin Absorption of Mercury and its Compounds: Fact or Myth?

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Mercury and its compounds can be absorbed through the skin, despite the skin's waterproof nature. While the skin acts as a barrier, certain substances can penetrate it, particularly lipid-soluble compounds and very small molecules. The discussion highlights that water absorption can occur, as evidenced by skin pruning after prolonged exposure to water, suggesting that similar mechanisms could allow for mercury absorption. The effectiveness of skin absorption also depends on contact time with the substance. This principle is utilized in transdermal patches for medications like nicotine and birth control. The conversation raises the possibility of using skin patches for vitamin delivery, indicating interest in transdermal applications beyond traditional methods.
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I heard and read that mercury and some of its compounds can get absorbed through the skin how could it do that ?

Aren't our skins soposed to be waterproof ? I don't think that while washing our hands with water the water pases through the epidermis.
 
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Well actually, if you have ever gone swimming or have taken a long bath before, then you've probably noticed your fingers started to prune. I bilieve the pruning is caused by the absoption of water. Right? Because the water would flow into our cells because they have a lower conc of water than the surroundings.

So i supose that if this is the case then mercury could probably do the same.
 
Chemicals are easily absorbed through the skin. That's why you see "patches" for nicotine and birth control.

Here is a good site that discusses it.

http://www.cape.ca/children/derm2.html
 
Lipid soluble compounds can fairly easily pass through the skin, as can very small molecules. Water soluble compounds don't have as easy of a time, because the cell membrane has the hydrophobic portion of the lipid bilayer facing "outward." They can still get in, but you'd have to soak for a much longer time. Actually, for anything passing through the skin, contact time is important.
 
Ah, so can I take my vitamins through my skin? Like wear patches that last a week?
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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