The largest study conducted to date was the INTERPHONE study, which was conducted in 13 countries with 16 centers. This was an interview-based case-control study and involved 2409 meningioma, 2708 glioma cases and matched controls. The studies included patients 30–59 years.
The results showed the absence of increased risk of glioma with use of mobile phones. There was suspicious of an increased risk of glioma at the highest exposure levels, but further investigation is needed in order to draw safe conclusions [
20]. It is of note that the overall ORs in some of the included studies were <1.0, suggesting possible methodological drawbacks. In fact in the studies included in the INTERPHONE study no blinding was used. Finally a large prospective study that investigated the association of mobile phone use and incidence of intracranial tumors and other cancers in 791,710 middle-aged women in UK found no appreciable association for glioma or meningioma [
28]. A Danish cohort study that included 358,403 subscription holders accrued 3.8 million person years found no increased risk for glioma even for individuals with more than 13 years of subscription [
29]. Other older studies also showed no strong relation between mobile phone use and gliomas (Table
1) [
10–
16].