Spin wavefunction for 2 electrons

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In 4-D Hilbert space, the spin wavefunctions for two identical electrons, such as |up1>|down2> and |down1>|up2>, are equivalent due to the indistinguishable nature of electrons as Fermions. The exchange of these electrons results in a change of sign in the wavefunction, reflecting their antisymmetric properties. This characteristic is crucial in quantum mechanics, as it influences the overall behavior of systems with multiple identical particles. The discussion highlights the importance of understanding exchange symmetry in quantum states. Overall, the equivalence of these spin configurations is a fundamental aspect of quantum mechanics for identical particles.
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In 4-D Hilbert space for 2 electrons is |up1>|down2> equivalent to |down1>|up2> due to electrons being identical ?
 
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Time reversal invariant Hamiltonians must satisfy ##[H,\Theta]=0## where ##\Theta## is time reversal operator. However, in some texts (for example see Many-body Quantum Theory in Condensed Matter Physics an introduction, HENRIK BRUUS and KARSTEN FLENSBERG, Corrected version: 14 January 2016, section 7.1.4) the time reversal invariant condition is introduced as ##H=H^*##. How these two conditions are identical?

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