Mitochondrial Mutation & Increased State 4 Respiration

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SUMMARY

The discussion centers on a patient with a mitochondrial mutation leading to lethargy, characterized by increased state 4 respiration and normal state 3 respiration. The participant speculated that the mutation may cause increased leak across the inner mitochondrial membrane, affecting the proton motive force (PMF) and activating the respiratory chain. However, the correct explanation provided in the linked image clarifies the underlying mechanisms, which the participant finds difficult to comprehend.

PREREQUISITES
  • Understanding of mitochondrial respiration states (state 3 and state 4)
  • Knowledge of proton motive force (PMF) in cellular respiration
  • Familiarity with mitochondrial membrane dynamics
  • Basic concepts of genetic mutations and their physiological effects
NEXT STEPS
  • Research mitochondrial respiration and the differences between state 3 and state 4 respiration
  • Study the role of proton motive force in ATP synthesis
  • Explore the effects of mitochondrial mutations on cellular metabolism
  • Investigate experimental techniques for assessing mitochondrial function, such as the ADP addition experiment
USEFUL FOR

This discussion is beneficial for medical students, biochemists, and researchers focused on mitochondrial biology and its implications in metabolic disorders.

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i was undertaking a question regarding a patient who had a mutation in their mitochondria, and hence experienced lethargy. A subsequent test of his mitochondria found his mitochondria to have an increased state 4 respiration, but a normal state 3 respiration.

In order to explain this, I would have thought that perhaps some mutation has results in increased leak across the inner mitochondrial membrane, dissipating the PMF and thus electric field across the membrane, in turn activating the respiratory chain. However, the answer for the question was:

http://img94.imageshack.us/img94/9099/screenshot20100411at184.png

Can someone explain this answer to me; i am unable to understand it; and what is wrong with my explanation?

Thank you!
 
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It would help if you copied the entire question. I don't understand the ADP addition experiment from what you copied alone.