What principle explains the solubility of a substance in aqueous acid or aqueous base? Ionic solutes and its dissociation is involved in a substance's solubility in an aqueous acid or base. This solubility can be expressed by a chemical equation in which a basic salt results when a a weak acidic organic compound is in the presence of a strong base. This basic salt is then more soluble in the aqueous base than in water. A weak basic organic compound would then be more soluble in an aqueous acid. I don't know if this correctly/completely explains the substance's solubility. Thanks for any help.