kadiot
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First of all, the cytokine dysregulation ("storm" is such a loaded term, there are degrees - even storms have categories) involves not just bradykinin but a whole host of cytokines including IL-6 and the renin-angiotensin system. It also involves a whole lot of cells including T-cells, macrophages and endothelial cells. The reason why bradykinin is getting a lot of attention is because it seems to have a role ON TOP of all these other things going on. It is by no means the most important part of the response, but we do need to better define its role - along with all the other cytokines and immune processes going on. If it has a more significant role than in other diseases, then that is important and needs to be studied, but this story is by no means solved.
As an example, while bradykinin causes "leaky blood vessels," a major pathophysiologic manifestion of severe COVID-19 is CLOTS. This is what causes the strokes and some of the heart attacks. There are OTHER THINGS causing problems in COVID-19 and bradykinin is just ONE of them.
A supercomputer was used to generste the hypothesis, but the programming and inputs were made and interpreted by humans. I expect supercomputer AI to continue to get better in specialized tasks and act side-by-side with researchers/scientists.https://elemental.medium.com/a-supe...teresting-new-theory-has-emerged-31cb8eba9d63
As an example, while bradykinin causes "leaky blood vessels," a major pathophysiologic manifestion of severe COVID-19 is CLOTS. This is what causes the strokes and some of the heart attacks. There are OTHER THINGS causing problems in COVID-19 and bradykinin is just ONE of them.
A supercomputer was used to generste the hypothesis, but the programming and inputs were made and interpreted by humans. I expect supercomputer AI to continue to get better in specialized tasks and act side-by-side with researchers/scientists.https://elemental.medium.com/a-supe...teresting-new-theory-has-emerged-31cb8eba9d63