What Type of Chemical Bonds Exist Between Tight Junctions in Human Cells?

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SUMMARY

Tight junctions in human cells are primarily formed by interactions between claudin and occludin proteins. The chemical bonds that exist between these proteins are predominantly hydrogen bonds, which facilitate the strong adhesion between adjacent epithelial cells. This structural integrity is crucial for maintaining the barrier function of tissues, particularly in the skin. Understanding these interactions is essential for insights into cellular communication and tissue development.

PREREQUISITES
  • Knowledge of protein structures, specifically claudin and occludin.
  • Understanding of cellular junctions and their roles in epithelial tissues.
  • Familiarity with chemical bonding types, particularly hydrogen bonds.
  • Basic concepts of human cell biology and tissue development.
NEXT STEPS
  • Research the role of claudin and occludin in tight junction formation.
  • Explore the significance of hydrogen bonds in protein interactions.
  • Investigate the implications of tight junctions in epithelial tissue function.
  • Study the developmental biology of epithelial tissues in various animal models.
USEFUL FOR

This discussion is beneficial for cell biologists, molecular biologists, and researchers focused on epithelial tissue dynamics and cellular adhesion mechanisms.

Matt204823545
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What type of bonds are there in them?
I know tight junctions between adjacent cells are very strong and the gaps are practically zero. But what types of chemical bonds are they? Are they covalent bonds or hydrogen or ionic bonds? I mean between the claudin and occludin proteins.
 
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I started to answer. But. With no idea where this came from the answer is 'yes'. Not helpful at all. And downright pointless.

So fill us in, please. I'm pretty sure it is not plants:
1. Animal cells? What animals?
2. Tissue? Epithelial?
3. Developmental stage?

As a guess:
You can look up claudin which is probably what you want: https://en.wikipedia.org/wiki/Claudin

Actually, your question came close to being locked. We love good questions, this one has great potential, just no traction - i.e., details. Okay? So please realize that we do not see what you are looking at, pretend we're blind. Details help.
 
1595682654633.png


In almost all these images you seen loops (claudin, occludin) between adjacent cells that are almost touching, but not. My professor may have said (if I understood correctly) that they have hydrogen bonds between those loops. I think it's for human cells. For example between adjacent epithelial cells on the skin

From lecture slide:
1595683107828.png
 

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