TLC Analysis of a Synthesis Reaction

In summary, the conversation discusses an assignment about the synthesis of a compound and the factors that contribute to its success. The link provided contains the necessary information for the assignment. The conversation also includes questions about the process and the resulting products, as well as requests for visual representations using ChemDraw.
  • #1
irunshow
19
0
This is the link for the assignment: http://imageshack.us/f/840/assignmentsynthesisofev.jpg/


Homework Statement



Given in the link

Homework Equations



Why would the proposed synthesis be successful if the reaction stopped after 2 hrs?
How does H attack compound 2 to create compound 3?

The Attempt at a Solution



After 2 hrs. Compound 1 is higher than compound 2. Compound 1 is less polar than compound 2. So if that was the case, than the products would be compound 2.

I don't understand why H would react with the OH group and detach it away from Compound 2.


Thank you for the help!
 
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  • #2
You need to answer the following:

1. Why at 1 hour are there two spots and what do they represent. Draw them in ChemDraw.
2. What is likely in the pot at two hours.
3. Why is this initially-formed product at a lower Rf than the starting material.
4. Is it possible that the second product formed was a reaction product of your starting material and why or why not?
5. What is the likely structure of the second product. Use ChemDraw.
 
  • #3
^^ Thanks
 

1. What is TLC analysis?

TLC (Thin Layer Chromatography) is a common analytical technique used in chemistry to separate and identify the components of a mixture. It involves placing a small sample of the mixture on a thin layer of adsorbent material, such as silica gel or alumina, and then allowing a solvent to move up the layer via capillary action. The different components of the mixture will move at different rates based on their interactions with the adsorbent and solvent, allowing for their separation and identification.

2. Why is TLC analysis used in synthesis reactions?

TLC analysis is often used in synthesis reactions to monitor the progress of the reaction and determine the purity of the products. It can also be used to identify any impurities or side products that may have formed during the reaction.

3. How is TLC analysis performed?

To perform TLC analysis, a small amount of the reaction mixture is spotted onto the TLC plate and then placed in a developing chamber containing a suitable solvent. As the solvent moves up the plate, the components of the mixture will separate and form distinct spots. The plate is then visualized under UV light or by using a staining agent to identify the spots and measure their Rf values.

4. What are the advantages of TLC analysis?

TLC analysis is a quick, inexpensive, and relatively simple technique that does not require specialized equipment. It can provide valuable information about the progress and purity of a reaction in a relatively short amount of time. Additionally, TLC plates can be easily prepared in the laboratory using readily available materials.

5. What are some limitations of TLC analysis?

One limitation of TLC analysis is that it can only provide qualitative data, meaning it can identify the presence or absence of certain components but not their exact concentrations. It also requires a trained eye to accurately interpret the results, which can be subjective at times. In some cases, more advanced analytical techniques may be needed to fully characterize a reaction mixture.

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