Why do some COVID-19 patients die? New research reveals shocking cause

  • COVID
  • Thread starter Astronuc
  • Start date
  • Tags
    Covid-19
In summary, a breakthrough finding reveals that some Covid-19 patients, particularly men, may die due to their immune systems being attacked by autoantibodies. This was discovered in an international study involving 1,000 patients and led by the Covid Human Genetic Effort. Additionally, mutations in genes controlling interferons were found in 3.5% of critically ill patients. This new understanding may lead to targeted immunotherapy for these patients in the future. However, it is unclear if any immediate treatments have been developed based on this information.
  • #1
Astronuc
Staff Emeritus
Science Advisor
2023 Award
21,973
6,513
NBC News - 'Breakthrough finding' reveals why certain Covid-19 patients die
https://www.nbcnews.com/health/heal...ls-why-certain-covid-19-patients-die-n1247576
In some cases, provocative new research shows, some people — men in particular — succumb because their immune systems are hit by friendly fire. Researchers hope the finding will help them develop targeted therapies for those patients.

In an international study in Science, 10 percent of nearly 1,000 Covid-19 patients who developed life-threatening pneumonia had antibodies that disable key immune system proteins called interferons. These antibodies — known as autoantibodies, because they attack the body itself — weren't found at all in 663 people with mild or asymptomatic Covid-19 infections. Only four of 1,227 healthy patients had the autoantibodies. The study was led by the Covid Human Genetic Effort, which includes 200 research centers in 40 countries.

In a second Science study by the same team, the authors found that an additional 3.5 percent of critically ill patients had mutations in genes that control the interferons involved in fighting viruses.

Is this a major step in understanding how the virus works and eventually finding an improved treatment? Target immunotherapy?
 
  • Informative
  • Like
Likes atyy, FactChecker and Charles Link
Biology news on Phys.org

Related to Why do some COVID-19 patients die? New research reveals shocking cause

What are auto-antibodies and how do they relate to COVID-19?

Auto-antibodies are antibodies that mistakenly attack the body's own tissues and cells. In the case of COVID-19, auto-antibodies have been found to target specific proteins on the surface of the virus, potentially playing a role in the severity of the disease.

How do auto-antibodies develop in response to COVID-19?

Auto-antibodies can develop in response to an infection, such as COVID-19, when the body's immune system mistakenly identifies its own cells as foreign and produces antibodies to attack them. This can also happen in response to certain medications or underlying health conditions.

Can auto-antibodies be detected in COVID-19 patients?

Yes, auto-antibodies can be detected in COVID-19 patients through blood tests. These tests can help identify individuals who may be at a higher risk for developing severe symptoms and guide treatment options.

Do all COVID-19 patients have auto-antibodies?

No, not all COVID-19 patients have auto-antibodies. The presence of auto-antibodies varies among individuals and can depend on factors such as age, underlying health conditions, and the severity of the infection.

What is the significance of auto-antibodies in COVID-19 treatment and prevention?

The presence of auto-antibodies in COVID-19 patients may help researchers better understand the disease and develop more effective treatments and preventive measures. Additionally, identifying and monitoring auto-antibodies in individuals may help healthcare professionals make more informed decisions about their care.

Similar threads

  • Biology and Medical
Replies
12
Views
2K
  • Biology and Medical
Replies
8
Views
2K
  • Biology and Medical
Replies
12
Views
1K
  • Biology and Medical
Replies
1
Views
1K
  • Biology and Medical
Replies
2
Views
1K
Replies
2
Views
1K
  • Biology and Medical
Replies
1
Views
975
Replies
26
Views
3K
Replies
6
Views
3K
  • Biology and Medical
Replies
1
Views
815
Back
Top