Understanding Bombay Blood Group and its Compatibility for Blood Donation

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SUMMARY

The Bombay blood group, characterized by the genotype IoIo and hh, is distinct from the O blood group due to the absence of the H antigen. Individuals with the Bombay blood group can donate blood to any ABO blood type but can only receive blood from other Bombay blood group individuals. This restriction arises because they possess anti-H antibodies, which react against the H antigen present in O blood types. Conflicting information exists regarding the presence of H antibodies, with some sources asserting their existence while others deny it.

PREREQUISITES
  • Understanding of blood group genotypes, specifically Io and hh.
  • Knowledge of ABO blood group compatibility.
  • Familiarity with the concept of antigens and antibodies in blood transfusions.
  • Basic comprehension of genetic inheritance related to blood types.
NEXT STEPS
  • Research the genetic basis of the Bombay blood group and its implications for blood donation.
  • Study the role of H antigen in blood compatibility and transfusion reactions.
  • Examine the differences between Bombay blood group and other rare blood types.
  • Investigate the clinical management of patients with Bombay blood group in transfusion medicine.
USEFUL FOR

Medical students, healthcare professionals, blood bank technicians, and anyone involved in transfusion medicine or blood donation compatibility assessments.

Suraj M
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If an individual has a genotype##I^oI^o## and ##hh## is he considered to be O or bombay blood group?
Also i read that a person with bombay blood group can donate blood to anyone but can accept only from a person of his blood group, why can't he/she accept blood from O-ve?( is there a H antibody?)
 
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that answers my second question, but contradicts my teachers statement. :(
Thank you anyway,
Anyone for my first question?
 
Suraj M said:
If an individual has a genotype##I^oI^o## and ##hh## is he considered to be O or bombay blood group?

Would that individual be able to accept blood donations from an O-type individual or only from h/h-type individuals?
 
he can take from O, probably, but if there are H antibodies then , no!
My teacher said that There is no H antibody , but wikipedia says that there are..
 
Here's a more definitive reference which says there is an H antigen:

http://www.ncbi.nlm.nih.gov/books/NBK2268/

As I read the article more, it says people may have a deficit of the H so I'm looking for a better article to explain it.

I think your teacher meant to say that people with this blood type don't express the H antigen.
 
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I don't feel like trusting that article they say that parabombay blood group have a genotype HH, andthat they have anti-H, which i don't think exists naturally.
I asked another teacher, he said that though there might not be secifically H antibodies, but there will be some reaction, when blood(Hh/HH) is mixed with bombay blood group blood.
 
For your first question, yes, it is Bombay blood group since O has H not h.
There are anti-H antibodies according to my teacher who swears by Wikipedia :P
 
you have some interesting Bio questions :)
 
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