Think about a harmonic oszillator state |n>. Instead of interpreting this as a state with one particle in the n-th state we interpret it as n particles in a state. Acting with a the creation operator on this state does not send one particle in the (n+1) state, instead it creates a new particle.
For one state this is boring, so let's think about a collection of harmonic oscillators (uncoupled, commuting operators) with a state |k,m,n,...>. Now we have k particles in one state (of one harmonic oscillator), m particles in another state and so on.
In quantum field theory the different states in the ket |...> belong to different momenta p. If these momenta are quantized (particles in a finite box) the interpretation of the fock state |k,m,n,...> means that we have k particles in the ground state, m particles is the first excited state etc. Acting with creation and annihilation operators (now equipped with a label p) on these states creates and annihilates these particles. Interaction terms will usually couple these different states and e.g. do something like sending a state |m,k,n> to |k-1,m+1,n>.