Vaccinating after an infection

  • COVID
  • Thread starter artis
  • Start date
  • #1
994
280
Since the time has come for me to consider a single shot of either the pfizer or moderna vaccine I was wondering can someone more knowledgeable please explain to me , how exactly does the vaccine change the antibodies already present in my system?

I myself from the information I have understand that for someone who has had a previous infection there are antibodies to all the parts of the virus not just the spike protein while vaccinating with the mRNA vaccines produce antibodies to specifically the spike protein since that is the only protein being made by cells due to vaccine administration.
So would this then mean that for me having had a previous infection I will have the same levels of antibodies already present to the virus but an increased count of antibodies to the spike protein which I have already but at a lower level?

Does the administering of the vaccine in a previous infection case in any way affect the levels of antibodies (apart from spike protein) that are already present in my system ?
 

Answers and Replies

  • #2
.Scott
Homework Helper
2,885
1,149
There are two studies that address this:

Nature, June 14, 2021
The data suggest that immunity in convalescent individuals will be very long lasting and that convalescent individuals who receive available mRNA vaccines will produce antibodies and memory B cells that should be protective against circulating SARS-CoV-2 variants.
"convalescent individuals" = people who had been infected

Preprint server bioRxiv, August 8, 2021
Strikingly however, plasma from individuals who had been infected and subsequently received mRNA vaccination, neutralized this highly resistant SARS-CoV-2 polymutant, and also neutralized diverse sarbecoviruses. Thus, optimally elicited human polyclonal antibodies against SARS-CoV-2 should be resilient to substantial future SARS-CoV-2 variation and may confer protection against future sarbecovirus pandemics.

That first study basically says that following up an infection with an mRNA vaccine is a really good thing.

If I understand that second study correctly, it seems to be saying that your immune experience with the virus itself will change the immune response to the spike protein you generate with the vaccine - so that it is not only sensitive to the spike proteins it has encountered (from infection and vaccination), but to many variations in that protein. So if the normal response to a vaccination is a wanted poster describing a particular gang member, the enhanced response would be like a wanted poster describing how to recognize anyone in that gang.

To answer your question more directly, I can't tell from those studies (and others I've read) what the mRNA does to the "broad" virus recognition that you get from infection. Apparently, it does nothing. But the specific response to the COVID-19 spike protein (and apparently variations to that protein) is powerfully enhanced.
 
  • Like
Likes bhobba, atyy and Astronuc
  • #3
jim mcnamara
Mentor
4,441
3,176
In the second study @.Scott posted above, antibodies against the different SARS Coranavirus well as other known variant's epitopes were activated, not merely currently prevalent variants. So. Those epitopes were not actually in the vaccine. Consider your shot to be kind of a universal SARS vaccine.

So short answer: yes, you get extra protection.
 
  • Like
  • Informative
Likes berkeman, bhobba and Astronuc

Related Threads on Vaccinating after an infection

  • Last Post
Replies
6
Views
1K
  • Last Post
Replies
2
Views
3K
  • Last Post
Replies
5
Views
3K
Replies
4
Views
9K
  • Last Post
Replies
5
Views
1K
Replies
22
Views
604
Replies
2
Views
1K
Replies
7
Views
282
Replies
26
Views
9K
Top