Vagus Nerve & Acetylcholine: Lowering Heart Rate

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SUMMARY

The vagus nerve lowers heart rate primarily through the release of acetylcholine, a neurotransmitter that induces bradycardia by acting on muscarinic receptors in the heart. This mechanism contrasts with norepinephrine, which increases heart rate via adrenergic receptors. Understanding the precise action of acetylcholine at the cellular level is crucial for comprehending its role in cardiac physiology and potential therapeutic applications.

PREREQUISITES
  • Basic understanding of neurophysiology
  • Knowledge of neurotransmitter functions
  • Familiarity with cardiac physiology
  • Understanding of synaptic transmission
NEXT STEPS
  • Research the role of muscarinic receptors in cardiac function
  • Study the effects of acetylcholine on heart rate variability
  • Explore the interaction between acetylcholine and norepinephrine in autonomic regulation
  • Investigate therapeutic applications of vagus nerve stimulation
USEFUL FOR

Cardiologists, neuroscientists, medical students, and anyone interested in the autonomic regulation of heart rate.

gamecube999
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By releasing acetylcholine, how does the vagus nerve lower heart rate?
 
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Acetylcholine is a neurotransmitter released at nerve synapses that lowers heart rate (bradycardia). Its just one of its chemical properties. Norepinephrine is another neurotransmitter, except this one increases heart rate (tachycardia).
 
Yes but what I want to know is the precise mechanism of action of acetylcholine to lower heart rate?
 

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