What is the action of acetylcholine and anticholinesterase. Confused

  • Medical
  • Thread starter sameeralord
  • Start date
  • #1
663
3

Main Question or Discussion Point

What is the action of acetylcholine and anticholinesterase. Confused!!

Hello everyone,

Ok Acetylchlone is released from postganglionic parasympathetic fibres and preganglionic nerve fibres of both sympathetic and parasympathetic nerves. It also cause muscle contraction in neuromuscular junction. So anticholinesterase would increase acetylcholine level---> Now what would be the effects of increased acetylcholine. Ok I understand parasympathetic activity would be increased, but if lots of acetylcholine is there in preganglionic nerve fibres of sympathetic fibres now, shouldn't sympathetic activity also increase. So what is the final effect.Also in anticholinesterase poisoning what are the clinical effects. I can't work it out because of my previous confusion. Is is like pupillary constriction and bronchoconstriction if parasympathetic predominates. Also increased muscle contraction. Also if I use anticholinesterase in combination with a competitive agonist and neuromuscular blocking agent such as tubocurarine would this decrease the action of tubercurine, because now it has compete with acetylcholine.

Thanks for help in advance :smile:
 

Answers and Replies

  • #2
189
2


first high acetylcholine levels would be at the end organ level, not junction.

The effects of overdose is exactly like you said, plus a couple of other ones you can probably find onlline
 
  • #3
663
3


first high acetylcholine levels would be at the end organ level, not junction.

The effects of overdose is exactly like you said, plus a couple of other ones you can probably find onlline
Hey thanks for taking your time to help :smile: But could u please elaborate when you say "first high acetylcholine levels would be at the end organ level, not junction." Does this mean that if i give a cholinergic drugs (acetylcholine agonists), they will travel through the blood stream and reach the organs first, so by the time they reach nerve junctions there concentration would be very low hence minimum sympathetic activity.
 
  • #4
189
2


yeah thats what i am thinking, especially since acetylcholine's half life isnt that long to begin with.
 

Related Threads on What is the action of acetylcholine and anticholinesterase. Confused

Replies
2
Views
944
  • Last Post
Replies
4
Views
8K
Replies
3
Views
5K
  • Last Post
4
Replies
85
Views
46K
Replies
4
Views
27K
Replies
4
Views
2K
  • Last Post
Replies
2
Views
2K
Top