Warning of new opiod drug (nitazene) on the streets: Question re strength...

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SUMMARY

The discussion centers on the potency of nitazenes, a class of synthetic opioids, which are reported to be significantly stronger than both heroin and fentanyl. Users have noted that nitazenes can be found in street heroin and Oxycontin pills, raising concerns about accidental overdoses due to their unpredictable dosages. Naloxone, an opioid antagonist, is emphasized as critical for reversing overdoses, although multiple doses may be necessary due to the potency of nitazenes. The conversation highlights the lack of clinical use and quality control in the illegal production of these substances, contributing to the rising risks associated with their use.

PREREQUISITES
  • Understanding of opioid pharmacology, specifically mu-opioid receptors.
  • Knowledge of naloxone and its application in overdose situations.
  • Familiarity with the risks associated with synthetic opioids.
  • Awareness of the current opioid crisis and the role of illegal drug manufacturing.
NEXT STEPS
  • Research "nitazene mu-opioid receptor" for insights on receptor binding and effects.
  • Explore the pharmacodynamics of synthetic opioids to understand potency and efficacy.
  • Investigate the role of naloxone in emergency medical services for opioid overdoses.
  • Learn about the implications of drug adulteration in street drugs through resources like drugsdata.org.
USEFUL FOR

This discussion is beneficial for healthcare professionals, emergency responders, addiction specialists, and anyone involved in drug policy or harm reduction strategies related to opioid use.

  • #31
berkeman said:
Yes.


Yeah, as @Laroxe said, the effects of Narcan are short-lived, like 20-30 minutes or so. That's why it's still important to get the patient to the hospital even if they claim they are fine after they start breathing and wake up.
That explains the times I've seen someone wake up but doze off again as the opiate the person ODed on slowly retook the receptors. But yeah, as you say we're told to call the ambulance regardless.

EDIT: Sadly, I've lost count on all the times I've called an ambulance. I've had 2 people die from me. One because he was adamant on ending it. I called every authority imaginable, police, 112 (911 over there), family, his entire phone contact book, but he had threatened with doing it so many times that noone took it seriously. I was staring at a bunch of mixed pills 20 cm high. In the end I had to leave. You simply can't play babysitter for grown up people like that. Next day he was dead. What really p..... me off was that noone contacted me afterwards to hear what toll the experience took on me! And that was after an almost 20 minute conversation with police!

The other because I found him too late and there was nothing the EMTs could do.

EDIT: Even after immediately adminstering Naloxone nasally!

What a waste.

:mad:
 
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