What force makes muscles contract?

  • Thread starter Thread starter kolleamm
  • Start date Start date
  • Tags Tags
    Force
Click For Summary
SUMMARY

The discussion centers on the atomic-level mechanisms of muscle contraction, emphasizing the role of weak interactions between proteins rather than strong chemical bonds. Key processes include the binding of calcium ions (Ca++) to muscle proteins, which triggers conformational changes in protein structures, facilitated by ATP as the energy source. The complexity of these interactions involves various forces, including ionic bonds and hydrophobic attractions, highlighting the intricate nature of muscle fiber dynamics.

PREREQUISITES
  • Understanding of protein structure and function
  • Knowledge of ATP's role in cellular processes
  • Familiarity with calcium ion signaling in muscle physiology
  • Basic concepts of weak molecular interactions (e.g., ionic bonds, hydrophobic forces)
NEXT STEPS
  • Research protein crystallography techniques for detailed structural analysis
  • Explore the role of calcium ions in muscle contraction mechanisms
  • Study the biochemistry of ATP and its impact on protein shape changes
  • Investigate the various types of molecular interactions in biological systems
USEFUL FOR

Biochemists, molecular biologists, physiologists, and anyone interested in the detailed mechanisms of muscle contraction at the molecular level.

kolleamm
Messages
476
Reaction score
44
I know muslces have fibers and all sorts of structures but how do they actually attract themselves to each other on a very atomic level? Is it some sort fo chemical bonding force or?
 
Biology news on Phys.org
Its a complex process involving many changes in binding and changes in the shape of proteins that make up the fibers in the muscle cells.

Generally speaking, the binding of between two interacting proteins is not that strong. However, it would be repeated many many times in each muscle fiber where thousands or millions of interacting proteins would be involved. Binding sites are usually made by a mix of different weak interactions on the 3D surfaces of the two things being bound together. They usually don't involve covalent bonds, but may involve charge and other interactions.
The binding of two proteins may cause one or both proteins to change shape.
In addition to these general considerations on binding, ATP (cellular energy source) is involved in muscle contraction by driving certain changes in the protein shape. Shape changes such as this, in turn involve relatively weak interactions within the particular proteins, which drives their shape changes, which in turn causes muscle contraction.

It is usually triggered by an increase in Ca++ whihc binds to particular muscle proteins.

Muscles actively contract (shorten). They lengthen passively (no energy involved, no force generated, other muscles contraction causes them to lengthen).

Wikipedia has a extensive article in this. See the article for more details.


1008_Skeletal_Muscle_Contraction copy.jpg

Picture from here.
 
  • Like
Likes   Reactions: PeroK and kolleamm
BillTre said:
Its a complex process involving many changes in binding and changes in the shape of proteins that make up the fibers in the muscle cells.

Generally speaking, the binding of between two interacting proteins is not that strong. However, it would be repeated many many times in each muscle fiber where thousands or millions of interacting proteins would be involved. Binding sites are usually made by a mix of different weak interactions on the 3D surfaces of the two things being bound together. They usually don't involve covalent bonds, but may involve charge and other interactions.
The binding of two proteins may cause one or both proteins to change shape.
In addition to these general considerations on binding, ATP (cellular energy source) is involved in muscle contraction by driving certain changes in the protein shape. Shape changes such as this, in turn involve relatively weak interactions within the particular proteins, which drives their shape changes, which in turn causes muscle contraction.

It is usually triggered by an increase in Ca++ whihc binds to particular muscle proteins.

Muscles actively contract (shorten). They lengthen passively (no energy involved, no force generated, other muscles contraction causes them to lengthen).

Wikipedia has a extensive article in this. See the article for more details.

View attachment 253117
Picture from here.
Nice post, so would you say it would be something like an ionic bond contracting the muscles?
 
Something like an ionic bond (or maybe a weaker charge attraction) could be involved in some of the many aspects of the process (binding or attachment, shape changes).
Other attractive forces could also be involved like hydrophobic attraction.
There are so many different interactions going onin this complex process, that I hesitate to rule much out.
 
kolleamm said:
yes I have, the answers are too broad and not at the atomic level
I used to wonder the same thing. How does tissue actually contract.

When I saw it animated at the atomic level it brought a whole new visual element to it for me.

actin.gif


crossbridgecycle.gif
 
  • Like
Likes   Reactions: sandy stone, kolleamm and PeroK
I would hesitate to say I know exactly what kinds of binds are forming and breaking at an atomic level.
Determining what the interactions are the atomic level would require protein crystalolgraphy of its more modern equivalents that produce the kind of detail.
The blobs in many molecular models (such as @DaveC426913 or I showed in earlier posts) will contain thousands of millions of atoms. Tens or hundreds of these atoms may be involved in these kinds of interactions.
 

Similar threads

Replies
1
Views
3K
Replies
13
Views
2K
Replies
8
Views
3K
  • · Replies 4 ·
Replies
4
Views
1K
  • · Replies 8 ·
Replies
8
Views
3K
  • · Replies 12 ·
Replies
12
Views
4K
  • · Replies 1 ·
Replies
1
Views
2K
  • · Replies 10 ·
Replies
10
Views
2K
  • · Replies 3 ·
Replies
3
Views
6K
  • · Replies 13 ·
Replies
13
Views
23K