The discussion clarifies the distinctions between cytotoxic and cytogenotoxic substances. Cytotoxic agents are defined as those that kill cells, including cancer cells, while cytogenotoxic agents specifically cause mutations in DNA, potentially leading to cancer. The terms mutogenic and carcinogenic are also highlighted, indicating their roles in causing mutations and cancer, respectively. Additionally, the concept of genotoxicity is introduced, which affects DNA without necessarily causing mutations, impacting processes such as protein synthesis and gene regulation.
PREREQUISITESResearchers in cancer biology, toxicologists, and healthcare professionals interested in the effects of substances on cellular health and genetic integrity.
Mutogenic and carcinogenic are terms we use for causing mutation and cancer causing.SanjuktaGhosh said:I did a little research, but I'm not fully confident if what I found is correct.
Cytotoxic: Anything that kills cells (including cancer cells).
Cytogenotoxic: Anything that mutates the DNA of a cell (can lead to cancer).
Genotoxicity from a search relates to an affect on the DNA but not necessarily a mutation. So it may affect protein synthesis, gene regulation etc.pinball1970 said:Mutogenic and carcinogenic are terms we use for causing mutation and cancer causing.
Remember most mutations are neutral.
Cytotoxic is poisonous to the cell.