What Is the Frequency of the PKU Allele in European Populations?

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SUMMARY

The frequency of the PKU allele in European populations is derived from the incidence of phenylketonuria (PKU), which is approximately 1 in 10,000 births. Given that PKU is an autosomal recessive disorder, the frequency of the PKU allele (q) can be calculated using the Hardy-Weinberg principle, where q² equals the incidence rate. Therefore, q equals the square root of 1/10,000, resulting in a PKU allele frequency of approximately 0.01 or 1% in these populations.

PREREQUISITES
  • Understanding of autosomal recessive inheritance patterns
  • Familiarity with the Hardy-Weinberg equilibrium principle
  • Basic knowledge of population genetics
  • Ability to perform square root calculations
NEXT STEPS
  • Study the Hardy-Weinberg equilibrium and its applications in population genetics
  • Research the implications of autosomal recessive disorders on public health
  • Explore genetic testing methods for PKU detection
  • Investigate allele frequency calculations in different populations
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Geneticists, public health professionals, students studying genetics, and anyone interested in the epidemiology of genetic disorders.

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Homework Statement

The frequency of PKU in european populations is about 1/10000. What is the frequency of the allele for PKU?

The attempt at a solution

I know PKU is an autosomal recessive disorder so does that mean q^2=1/10000? I'm not quite sure where to go from here :bugeye:
 
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It's ok figured it out. :D
 

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