First note that if a=a' (mod 10) and b=b' (mod 10), then ab=a'b' (mod 10). So it always suffices to look at the last digits, ie, the numbers 0,1,...,9.
Say you start with 2. Then the powers of 2 mod 10 are 2,4,8,6,2,4,8,6,..., and so on. Note that once you get back to the original number, the pattern must repeat. Similarly, you can work out the following:
0,0,...
1,1,...
2,4,8,6,2,...
3,9,7,1,3,...
4,6,4,...
5,5,...
6,6,...
7,9,3,1,7,...
8,4,2,6,8,...
9,1,9,...
So, for example, the last digit of the power of any number ending in an 8 only depends on the power mod 4, eg, 25438678676843342258^185876586585265 ends in an 8, since 65 = 1 (mod 4). And you can't use a calculator to verify that, so you'll have to trust the theory.
You could try to work out similar patterns for bases other than 10, and see if you get any patterns to the patterns. This kind of thing is the subject of group theory or ring theory.