What is the role of insulin other than translocating GLUT-4 proteins?

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Insulin plays a crucial role in glucose metabolism by facilitating the translocation of GLUT-4 proteins to the plasma membrane in adipose and skeletal muscle cells, enhancing glucose uptake. In the liver, insulin regulates gluconeogenesis and promotes glycogen synthesis. However, insulin receptors are also found in various other tissues, prompting inquiries about insulin's functions in these areas, particularly since GLUT-4 is not present in all cells. The discussion highlights the need for scientific literature that explores insulin's roles beyond the well-known tissues, emphasizing the tissue-specific responses generated by insulin in muscle, vascular endothelium, heart, and liver cells. The search for relevant studies has proven challenging, indicating a gap in accessible information on this topic.
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What are the roles played by insulin in tissues where GLUT-4 is not known to be present?
Insulin's role in glucose metabolism by translocating GLUT-4 proteins into the plasma membrane (thereby regulating the uptake of glucose), in the adipose and skeletal muscle cells, is rather well known. And in the liver, insulin aids to regulate gluconeogenesis and promoting glycogen synthesis.

But it is also known that insulin receptors are present in many tissues other than the liver, adipose, and muscle cells. What are the roles that are played by insulin in those tissues, since GLUT-4 is not known to be present in other cells?

Are there any scientific papers that discuss such insulin's roles in other cells in its physiology?

Thanks in advance. I tried searching the internet, but couldn't find helpful.
 
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