What is the significance of high enzyme Km in enzyme regulation?

[gravenewworld]

I'm reading a reference right now on an enzyme I'm interested in, and the reported Km for the enzyme is in the mM range, which is much higher than the typical concentration of the enzyme's substrate that is found in the cell. The reference mentions "Enzymes often work at substrate concentrations below the Km, because the regulation of the
enzyme activity is easier then."Can anyone expound on this further? What does it mean? Where can I find more information on this statement? I'm having a hard time understanding that statement since biochemistry is not my expertise. I thought low Km was always better for regulation of the substrate, but why does high Km of the enzyme make it easier to regulate the enzyme?

 

[Ygggdrasil]

Consider the sensitivity of the enzyme activity to the concentration of substrate (i.e. dv/d, where v is the reaction rate). At which points is activity most sensitive to ? When is the enzyme least sensitive to changes in ?

 

[epenguin]

I an not sure that the statement by itself really means anything, but it is true that in some well known allosterically regulated enzymes an inhibitor or an activator work by changing the affinity, the 1/K_m or, if the kinetics are non-Michaelian, we must say the S_0.5 (the half-saturating substrate concentration) and not the V_max so in that case you can see...