Hey Sunshine, how would you like to do some calculations for yourself?
Let's start by assuming that the folk working on the NASA TPF (Terrestrial Planet Finder) or ESA Darwin projects* have got their science more or less right, and that they would be able to observe the spectra of Earth-like planets orbiting in the Habitable Zone around F, G, or K main sequence stars within 25 pc sufficiently well to detect the abundance of enough molecules in these planets' atmospheres to allow chemists to say what the likelihood that Earth-like life has a large part to play in the composition of these atmospheres is (whew, what a long phrase!).
Now, what would the size of the (space-based) instruments need to be to do the same trick for stars in the SMC or LMC**? Might there be other techniques that could be used (instead of a coronograph and nulling interferometer)?
Finally, other than projects like Darwin or the TPF, how else could we constrain the possibility Earth-like life on Earth-like planets? For now, let's leave aside SETI-type searches (this involves a whole different set of questions, from the "I").
*OK nitpickers, this is a composite objective, not exactly aligned with those of Darwin, or TPF-C or TPF-I; I'm trying to make things a bit simpler.
**caveat #2: OK, neither is, in fact, the closest galaxy to the MW, but each is sufficiently large and close that individual stars can be easily seen, and complications of looking through the MW plane (if any) are sidestepped.