For a simple (and useful) example for Minkowski spacetime, use "light-cone coordinates".
In my conventions, [tex]u\equiv t+x\qquad v\equiv t-x[/tex]
and [tex]\hat u\equiv \frac{1}{2}\left( \hat t+\hat x \right)\qquad \hat v\equiv \frac{1}{2}\left( \hat t-\hat x \right).[/tex]
where [itex]\hat{}[/itex] indicates a basis vector (not necessarily a "unit-magnitude" vector).
(Other conventions use factors of [itex]\sqrt{2}[/itex].)
In my signature conventions, using the Minkowski-dot-product, [itex]\quad[/itex] [itex]\hat t \cdot \hat t=1[/itex], [itex]\quad[/itex] [itex]\hat x \cdot \hat x= -1[/itex], and [itex]\quad[/itex] [itex]\hat t \cdot \hat x=0[/itex].
postscript:
Although the basis vectors [itex]\hat u[/itex] and [itex]\hat v[/itex] point along the light cone, and they may look to have a Euclidean-angle of "90-degrees" between them, these basis vectors are not Minkowski-orthogonal (which you can check by computing the Minkowski-dot-product).