Where is glucose-6-phosphatase located?

  • #1

Summary:

Where in the cell is this enzyme located?

Main Question or Discussion Point

I have it as "located: embedded in the ER membrane" in my notes. Is this correct? Below is the image I use in my studies. Is this the only place in the cell where this enzyme is located? Is there a website that I can use to find the locations of enzymes in cells? Specifically: the human body only. Wikipedia doesn't really help.

 

Answers and Replies

  • #2
anuttarasammyak
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I do not have much knowledge on cell biology, but I assume your question is restated as "where in the cell the chemical reaction you are watching takes place?" because transportation of enzyme in the cell seems not probable to me.

Wiki Glucose 6-phosphatase :
However, the corresponding residue in glucose 6-phosphatase-α (Lys76) resides within the ER membrane and its function, if any, is currently undetermined. With the exception of Lys76, these residues are all located on the luminal side of the ER membrane.[4]

So I was wrong as for residue storage.
 
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  • #3
Ygggdrasil
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The human protein atlas is a good resource to get a general idea of where inside the cell many human proteins reside: https://www.proteinatlas.org/

The site has data for one of the subunits of glucose-6-phosphatase (G6PC3), and it shows that it is indeed localized to the endoplasmic reticulum: https://www.proteinatlas.org/ENSG00000141349-G6PC3/cell

However, this data cannot say that this is the only location that the enzyme is located. The type of experiment used to determine the location of the enzyme only really pinpoints where the majority of the enzyme resides and the experiment was only performed in a small number of cell lines. It is possible that a smaller fraction of the enzyme could be elsewhere inside of the cell, and it's possible that the location could differ in other cell lines.
 
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  • #4
The human protein atlas is a good resource to get a general idea of where inside the cell many human proteins reside: https://www.proteinatlas.org/

The site has data for one of the subunits of glucose-6-phosphatase (G6PC3), and it shows that it is indeed localized to the endoplasmic reticulum: https://www.proteinatlas.org/ENSG00000141349-G6PC3/cell

However, this data cannot say that this is the only location that the enzyme is located. The type of experiment used to determine the location of the enzyme only really pinpoints where the majority of the enzyme resides and the experiment was only performed in a small number of cell lines. It is possible that a smaller fraction of the enzyme could be elsewhere inside of the cell, and it's possible that the location could differ in other cell lines.

Thank you so much. That is EXACTLY what I was looking for and is what every university should provide to its biology students (why the heck don't they!?). I wish I found that website earlier. I can't thank you enough!
 
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