Physical reason? Well in some experiment... for exaple you have some target and you bomb that target with electrons. Electrons very quick louse their energy and you can't say is some electron in some other moment the electron you look in some other moment.
If you look two electrons and let's say that state of the system is [tex]\psi(\xi_1,\xi_2)[/tex], where [tex]\xi_1[/tex] and [tex]\xi_2[/tex] denoting the three coordinates and spin projection. And define some operator of permutation:
[tex]\hat{P}_{1,2}\psi(\xi_1,\xi_2)=\psi(\xi_2,\xi_1)[/tex]
Eigen problem of this operator is:
[tex]\hat{P}_{1,2}\psi(\xi_1,\xi_2)=\lambda\psi(\xi_1,\xi_2)[/tex]
[tex]\Rightarrow \lambda=\pm1[/tex]
[tex]\lambda=-1[/tex] - fermions
[tex]\lambda=1[/tex] - bosons