- #1
Ahmed Abdullah
- 203
- 3
I asked this question in some other place but they had simply said that .. the DNA polymerase don't have the ability to start DNA polymerization but I already know that and it doesn't answer my question.
RNA is not much different from DNA (virtually same as far as polymerization reaction is concerned). If RNA polymerase can start without any primer ... it seems that there is not much mechanistic problem for DNA polymerase in doing so. Does it has something to do with accuracy? Like, the kind of design required to start polymerization from scratch comes at the cost of fidelity (i.e replication process become more error prone). Or there is a fundamental difference (completely different mechanism) in the way RNA polymerase and DNA polymerase work?
By the way a complementary question, why RNA polymerase has low fidelity?
RNA is not much different from DNA (virtually same as far as polymerization reaction is concerned). If RNA polymerase can start without any primer ... it seems that there is not much mechanistic problem for DNA polymerase in doing so. Does it has something to do with accuracy? Like, the kind of design required to start polymerization from scratch comes at the cost of fidelity (i.e replication process become more error prone). Or there is a fundamental difference (completely different mechanism) in the way RNA polymerase and DNA polymerase work?
By the way a complementary question, why RNA polymerase has low fidelity?