I haven't read the entire thread, and I hope, I'm not repeating the obvious once more.
Before thinking in terms of relativity it helps to first look at the issue from a Newtonian point of view. In this context the question is of course related to Newton's 1st postulate. This postulate states that there exists a special class of reference frames, where the "principle of inertia" holds: A body, unaffected by any force, stays at rest or in uniform rectilinear motion (or shorter: moves with constant velocity within this frame of reference). It also follows that there is no way to distinguish any inertial reference frame from another, i.e., all motion can only be described relative to some inertial frame, but all the physical laws are the same in all inertial frames. So there is no distinguished inertial frame of reference.
Now there is special relativity, where also Newton's 1st postulate holds true, but as Einstein famously figured out in 1905, in order to make it valid to hold also for electromagnetic phenomena, one has to change the spacetime description to Minkowski spacetime, and the transformation between different inertial reference frames must be done with Poincare (Lorentz) transformations rather than Galilei transformations, including the change of the time "coordinate" such that the speed of light in vacuum is the same in all frames, independent of the velocity of the light source.
Finally, there's also Einstein's general theory of relativity, which he had to introduce in order to describe gravity within a relativistic framework. The upshot is that inertial frames exist only locally, i.e., you can always find a frame of reference in a small "space-time volume", where for all local phenomena the laws as described by special relativity and without gravity hold true. These are determined by (non-rotating) free-falling frames of reference. In a small enough region within such a free-falling frame of reference Newton's law of inertia holds true and there is (almost) no gravity acting on a body, i.e., it will move with constant velocity relative to this local inertial frame of reference.
Now I always emphasized that this holds only locally, i.e., for sufficiently small space-time volumes. That's because if there is a true gravitational field around, you can never get rid of this gravitational field simply by choosing any frame of reference. If you look only at long enough distances you'll always have an effect of the gravitational field, the socalled tidal forces, and that's described in general relativity by the fact that at presence of true gravitational fields the spacetime is described by a space with curvature.
So to answer the original question: In GR there are always local inertial frames of reference, and these are realized by free-falling non-rotating reference frames, and wrt. such a local inertial reference frame Newton's Law of Inertia still holds for not too large neighborhoods around the free falling "origin" of this reference frame.