Why does porphyria give neurological symptoms?

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  • Thread starter sameeralord
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Main Question or Discussion Point

Hello everyone,

What I have read says they are exactly not sure. Can any one say something about this, or give some link that tries to explain this. Thank you :smile:
 

Answers and Replies

  • #2
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My understanding is that the problem isn't actually the lack of porphyrin rings (for heme groups mostly), but instead the build up of toxic intermediates in the synthetic pathways. I assume that the exact location of a problem in the pathway determines where these toxins build up; it is common for acute neurological symptoms to arise from mitochondrial problems, however---maybe thats where the problem lies.

Porphyria is fairly well studied, if you want the details I think a 'pubmed' search would be very helpful.
 

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