Why Don't NAD+ Levels Increase Significantly in Humans?

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NAD+ precursors like NMN and NR are effective in increasing NAD+ levels in mice but show limited efficacy in humans. The discussion highlights the challenges in translating these findings from animal models to human physiology, particularly regarding the mechanisms that regulate NAD+ levels in humans. Factors that prevent significant increases in NAD+ include differences in metabolism and cellular uptake of these precursors. Research indicates that while various strategies to boost NAD+ have demonstrated benefits in preclinical studies, the translation to human health remains complex. The referenced study reviews NAD+ biochemistry and its implications for health and disease, emphasizing the ongoing exploration of NAD+ boosters for enhancing healthspan and lifespan.
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Can NAD+ conversion in humans be increased?
As I understand it only in mice do precursors like nmn and nr readily get turned into NAD+ in the cells. But not so much in humans? What keeps NAD+ levels from increasing in people in any meaningful way?
 
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I googled and found:

https://www.semanticscholar.org/paper/NAD+-homeostasis-in-health-and-disease.-Katsyuba-Romani/9970f02833257350da64318d54e075c203701c69
NAD+ homeostasis in health and disease
Elena Katsyuba, Mario Romani, Dina Hofer and Johan Auwerx
Nature metabolism 2:9–31 (2020)
"In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research."
 
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