Why Don't NAD+ Levels Increase Significantly in Humans?

  • Thread starter Thread starter LightningInAJar
  • Start date Start date
  • Tags Tags
    Increasing
AI Thread Summary
NAD+ precursors like NMN and NR are effective in increasing NAD+ levels in mice but show limited efficacy in humans. The discussion highlights the challenges in translating these findings from animal models to human physiology, particularly regarding the mechanisms that regulate NAD+ levels in humans. Factors that prevent significant increases in NAD+ include differences in metabolism and cellular uptake of these precursors. Research indicates that while various strategies to boost NAD+ have demonstrated benefits in preclinical studies, the translation to human health remains complex. The referenced study reviews NAD+ biochemistry and its implications for health and disease, emphasizing the ongoing exploration of NAD+ boosters for enhancing healthspan and lifespan.
LightningInAJar
Messages
251
Reaction score
33
TL;DR Summary
Can NAD+ conversion in humans be increased?
As I understand it only in mice do precursors like nmn and nr readily get turned into NAD+ in the cells. But not so much in humans? What keeps NAD+ levels from increasing in people in any meaningful way?
 
Biology news on Phys.org
I googled and found:

https://www.semanticscholar.org/paper/NAD+-homeostasis-in-health-and-disease.-Katsyuba-Romani/9970f02833257350da64318d54e075c203701c69
NAD+ homeostasis in health and disease
Elena Katsyuba, Mario Romani, Dina Hofer and Johan Auwerx
Nature metabolism 2:9–31 (2020)
"In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research."
 

Thread 'Body dysmorphic disorder (BDD)'

https://www.nhs.uk/mental-health/conditions/body-dysmorphia/ Most people have some mild apprehension about their body, such as one thinks their nose is too big, hair too straight or curvy. At the extreme, cases such as this, are difficult to completely understand. https://www.msn.com/en-ca/health/other/why-would-someone-want-to-amputate-healthy-limbs/ar-AA1MrQK7?ocid=msedgntp&cvid=68ce4014b1fe4953b0b4bd22ef471ab9&ei=78 they feel like they're an amputee in the body of a regular person "For...
View full post »
Thread 'Did they discover another descendant of homo erectus?'

Thread 'Did they discover another descendant of homo erectus?'

The study provides critical new insights into the African Humid Period, a time between 14,500 and 5,000 years ago when the Sahara desert was a green savanna, rich in water bodies that facilitated human habitation and the spread of pastoralism. Later aridification turned this region into the world's largest desert. Due to the extreme aridity of the region today, DNA preservation is poor, making this pioneering ancient DNA study all the more significant. Genomic analyses reveal that the...
View full post »

Similar threads

Can Broccoli and NMN Help Slow Down the Aging Process?
Replies
13
Views
13K
Difference between symbionts and parasites
Replies
2
Views
2K
Mice Have Longer Lives If Taking Bodybuilding Supplement
Replies
9
Views
2K
(Mice) Interleukin 17a and anxiety
Replies
1
Views
1K
Virus mutation by artificially guided selection
Replies
15
Views
2K
Why Apes and Humans don't have Tails
Replies
8
Views
3K
I need help understanding this quote about recent Natural Selection
Replies
20
Views
256
How human strength can increase without increased muscle size?
Replies
13
Views
2K
The predictive brain (Stimulus-Specific Error Prediction Neurons)
Replies
15
Views
3K
COVID How Does Vaccination After Infection Affect Existing Antibodies?
Replies
2
Views
1K

Hot Threads

Recent Insights

Back
Top