PPAR-gamma, known as peroxisome proliferator-activated receptor gamma, was initially identified in Xenopus frogs as a receptor that induces the proliferation of peroxisomes in cells. The discovery of PPARs, including PPAR-alpha, occurred during research on peroxisome proliferators, which are agents that increase peroxisomal numbers in rodent liver tissue while also enhancing insulin sensitivity. Originally linked to fibrates in the early 1980s, the term "PPAR ligands" emerged as the broader biological roles of these receptors were uncovered, with thiazolidinediones being the most recognized PPAR ligands.
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https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptorPPARs were originally identified in Xenopus frogs as receptors that induce the proliferation of peroxisomes in cells.[7] The first PPAR (PPARα) was discovered during the search of a molecular target for a group of agents then referred to as peroxisome proliferators, as they increased peroxisomal numbers in rodent liver tissue, apart from improving insulin sensitivity.[8] These agents, pharmacologically related to the fibrates were discovered in the early 1980s. When it turned out that PPARs played a much more versatile role in biology, the agents were in turn termed PPAR ligands. The best-known PPAR ligands are the thiazolidinediones; see below for more details.