The discussion focuses on calculating the absorbed dose for specific organs using mathematical formulas, particularly for the radionuclide Ra-223 in the liver. The Committee on Medical Internal Radiation Dose (MIRD) provides standardized methods and models for assessing internal radiation doses from radiopharmaceuticals. MIRD simplifies the complex dosimetric analyses, making it easier to calculate organ doses through established methodologies and software tools. For detailed guidance, users are encouraged to refer to MIRD resources available online.
PREREQUISITESThis discussion is beneficial for medical physicists, radiation oncologists, and healthcare professionals involved in radiation therapy and dosimetry calculations.
Committee on Medical Internal Radiation Dose (MIRD)
Radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. The MIRD Committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. The MIRD approach simplifies the problem of assessing dose for many different radionuclides—each with its unique radiological characteristics and chemical properties as labeled compounds—in the highly diverse biological environment represented by the human body, internal organs, tissues, fluid compartments, and cells. The virtue of the MIRD approach is that it systematically reduces complex dosimetric analyses to methods that are relatively simple to use, including software tools for experimental and clinical use.