Best way to neutralize alcohol in your body?

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Discussion Overview

The discussion revolves around methods to neutralize or digest alcohol in the body after intoxication. Participants explore various approaches, including the role of enzymes, hydration, and potential chemical interactions, while considering the physiological processes involved in alcohol metabolism.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants propose that drinking substances with acetic acid might facilitate esterification to expedite alcohol elimination.
  • Others argue that the only reliable method to eliminate alcohol is through time and the body's natural processes, specifically the action of alcohol dehydrogenase.
  • A participant questions the effectiveness of consuming alcohol dehydrogenase directly, considering the rapid absorption of alcohol into the bloodstream.
  • There is a suggestion that drinking water can help alleviate hangover symptoms by addressing dehydration, although its effectiveness in speeding up alcohol elimination is debated.
  • Some participants mention that alcohol dehydrogenase may be denatured by stomach acids, questioning the viability of enzyme supplementation.
  • One participant notes that ethanol is used as an antidote for antifreeze poisoning, suggesting a potential reverse effect, but warns against attempting this method.
  • Another participant mentions that while drinking water increases urination, it does not necessarily enhance the kidneys' ability to eliminate alcohol more quickly.
  • A later reply introduces the idea of inhibiting alcohol dehydrogenase with a nicotinamide analog to prolong intoxication effects.
  • There is mention of a specific antagonist to alcohol's action at GABA receptors, developed by Hoffmann La Roche, called Ro 15-4513.

Areas of Agreement / Disagreement

Participants express a range of views on the effectiveness of different methods to neutralize alcohol, with no consensus reached on a definitive solution. Some agree on the importance of hydration, while others challenge its efficacy in speeding up alcohol elimination.

Contextual Notes

Limitations include the lack of consensus on the effectiveness of various proposed methods and the dependence on individual physiological responses to alcohol and hydration.

wasteofo2
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Is there an easy way to help neutralize/digest alcohol once you're intoxicated? For instance, would drinking lots of things with aceitic acid cause esterification to occur within your body, getting the alcohol out quicker? Is there something else that could be done?
 
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wasteofo2 said:
Is there an easy way to help neutralize/digest alcohol once you're intoxicated? For instance, would drinking lots of things with aceitic acid cause esterification to occur within your body, getting the alcohol out quicker? Is there something else that could be done?



Time is the only way. The are probably as many ways to try to get rid of alcohol/kill hangovers as there are to get drunk in the first place. The only way to get rid of alcohol faster would be to tell your body to make more alcohol dehydrogenase. But there is nothing you can do about that.
 
Your body's elimination of alcohol from your blood is a zero order reaction done by the alcohol dehydrogenase enzyme in your liver, meaning that it doesn't depend on the temperature of concentration of the alcohol, just how much alcohol dehydrogenase you have.

As delicious as it sounds, I wonder, if you could drink a glass of alcohol dehydrogenase miture and have it start to work breaking down the alcohol when it is still being digested?
But since alcohol is absorbed into the blood stream so quickly, I wonder how effective that would be?
 
gravenewworld said:
The are probably as many ways to try to get rid of alcohol/kill hangovers as there are to get drunk in the first place.
Well now, getting rid of - or avoiding - hangovers is a completely different matter than neutralizing the alcohol. And there's really only one, ultra-simple way of doing that: drink lots of water. Most of the symptoms of a hangover are a result of dehydration.
 
I wonder, if you could drink a glass of alcohol dehydrogenase miture and have it start to work breaking down the alcohol when it is still being digested?

Unfortunately I think the rather strong acids in your stomach would denature the enzyme faster than it would get to the alcohol. I remember hearing at school that alcohol (pure ethanol) was the antidote for antifreeze poisioning so I guess it might work in the reverse situation (I wouldn't recommend trying it though!)
 
sophster said:
Unfortunately I think the rather strong acids in your stomach would denature the enzyme faster than it would get to the alcohol. I remember hearing at school that alcohol (pure ethanol) was the antidote for antifreeze poisioning so I guess it might work in the reverse situation (I wouldn't recommend trying it though!)

Remember that 'alcohol' is a trivial name for ethanol, but that does bot mean that all alcohol found in bars etc. is pure ethanol.
 
sophster said:
Unfortunately I think the rather strong acids in your stomach would denature the enzyme faster than it would get to the alcohol. I remember hearing at school that alcohol (pure ethanol) was the antidote for antifreeze poisioning so I guess it might work in the reverse situation (I wouldn't recommend trying it though!)


Getting hammered is also a "cure" for wood alcohol i.e. methanol poisoning.
 
sophster said:
I remember hearing at school that alcohol (pure ethanol) was the antidote for antifreeze poisioning so I guess it might work in the reverse situation (I wouldn't recommend trying it though!)
Don't try it. Antifreeze in and of itself isn't poisonous, but enzymes in the liver turn it into oxalic acid, which is poisonous. Ethanol inhibits those enzymes long enough for the antifreeze to be excreted safely... so drinking antifreeze to "cure" being drunk would have little effect. The ethanol would shield you from its effects... but it wouldn't affect the ethanol's effects.
 
hmmm... actually there is a way to get ride of the alcohol in the body, my advise is that u should drink lots of water here are the reasons why;

1. drinking water causes you to urinate, thus urinating help you to eliminate alcohol in your bloodstream
2. alcohol deprives you of your bodily fluids, which is very dangerous you might die sleeping ^_^ [this is serious though] - drinking water is the best natural way to get ride of alcohol in the body
 
  • #10
marc_ocampo said:
1. drinking water causes you to urinate, thus urinating help you to eliminate alcohol in your bloodstream

Drinking water won't make your kidneys work any faster (possibly the opposite), it'll just give you more diluted urine. And it doesn't really matter whether you urinate or not because the alcohol can't really be reabsorbed from your bladder.

This thread's four years old btw.
 
  • #11
On the other hand it has been suggested you might inhibit the alcohol dehydrogenase with a nicotinamide analog if you want to prolong the effect. Suggested, but not too seriously.
 
  • #12
There exist a specific antagonist to the action of alkohol at the relevant GABA receptors which had been developed by Hoffmann La Roche and is called Ro 15-4513.
 

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