Boost Response by Delaying Second Dose -- Pfizer vaccine in elderly

In summary, a study has found that waiting 11-12 weeks for the second dose of the Pfizer vaccine may result in higher antibody levels in older individuals compared to waiting only 3 weeks. While the Pfizer vaccine has already been shown to be highly effective in older individuals, this data could be useful in developing future vaccines with potentially lower doses and longer spacing between doses.
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Tom.G
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This applies to the Pfizer vaccine. Article dated May 13, 2021.

https://www.nature.com/articles/d41586-021-01299-y

Older people who waited 11–12 weeks for their second jab had higher peak antibody levels than did those who waited only 3 weeks. ...could boost antibody responses after the second inoculation more than threefold in those older than 80. (bold added)

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Tom
 
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The Pfizer vaccine has already been observed to be very effective in older individuals (the original Phase III trial observed a 100% vaccine efficiency for those >75 (though this was based on a fairly low # of people) and real world data from Israel indicated a 95% protection for those > age 70. So, delaying the second dose probably would not increase protection very much (hard to do much better than 95% protection) and could actually lead to more disease if the protection before the second dose in weeks 3-11 is not effective as the protection from getting a second dose at week 3.

However, this data could be useful in designing vaccines going forward. For example, future vaccines might be able to use a lower dose of vaccine (which would hopefully have lower side effects) with greater spacing to achieve similar levels of protection.
 

Related to Boost Response by Delaying Second Dose -- Pfizer vaccine in elderly

1. What is the purpose of delaying the second dose of the Pfizer vaccine in elderly individuals?

The purpose of delaying the second dose of the Pfizer vaccine in elderly individuals is to potentially boost the immune response and provide better protection against COVID-19. This strategy is based on studies that have shown a stronger immune response in older adults when the second dose is given later.

2. How long is the delay for the second dose of the Pfizer vaccine in elderly individuals?

The delay for the second dose of the Pfizer vaccine in elderly individuals is currently recommended to be 12 weeks or more, based on the latest guidance from health authorities. This delay may vary depending on the availability of the vaccine and local vaccination policies.

3. Is it safe to delay the second dose of the Pfizer vaccine in elderly individuals?

There is currently no evidence to suggest that delaying the second dose of the Pfizer vaccine in elderly individuals is unsafe. In fact, studies have shown that a longer interval between doses may lead to a stronger immune response and better protection against COVID-19.

4. Will delaying the second dose of the Pfizer vaccine in elderly individuals affect the effectiveness of the vaccine?

There is currently no evidence to suggest that delaying the second dose of the Pfizer vaccine in elderly individuals will affect the effectiveness of the vaccine. In fact, some studies have shown that a longer interval between doses may result in a stronger immune response and better protection against COVID-19.

5. Should all elderly individuals receive the second dose of the Pfizer vaccine on a delayed schedule?

The decision to delay the second dose of the Pfizer vaccine in elderly individuals should be made on an individual basis, taking into consideration factors such as age, overall health, and risk of exposure to COVID-19. It is important to consult with a healthcare professional for personalized recommendations.

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