Brain Death and Revival: What Happens When the Heart Stops Beating?

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Discussion Overview

The discussion revolves around the physiological processes that occur when the heart stops beating, particularly focusing on brain function and the potential for revival. Participants explore the timeline of brain activity cessation, comparisons between brain states during sleep and post-cardiac arrest, and anecdotal experiences of patients who have been revived.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants propose that neurons begin to die approximately 5-6 minutes after oxygen deprivation occurs due to cardiac arrest.
  • There is speculation about the difficulty of conducting experiments comparing brain activity in sleeping individuals to those whose hearts have stopped, with ethical concerns raised about such studies.
  • One participant mentions that the brain of a person who has just experienced a heart attack would exhibit different rhythms compared to a sleeping brain, suggesting a trauma state versus a regulated sleep state.
  • Some participants share anecdotal accounts of what revived patients recall, with references to common phrases like "What the %#@& happened!?" and experiences of seeing bright lights, though this is noted as a topic not permitted for discussion on the forum.
  • Another participant highlights the difference in low-oxygen responses between in vivo and in vitro conditions, noting that neurons in a controlled environment can survive longer without oxygen compared to those in a living organism.

Areas of Agreement / Disagreement

Participants express various viewpoints and uncertainties regarding the timeline of brain function cessation and the experiences of revived patients. No consensus is reached on the specifics of these processes or the implications of the findings discussed.

Contextual Notes

Limitations include the lack of empirical studies directly comparing brain activity in different states and the reliance on anecdotal evidence regarding patient experiences post-revival.

MathJakob
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From the moment a persons heart stops beating, stop functioning, how long does it take until the brain starts to shut down and how long until it's completely non functional and you're dead beyond the point of revival?

It's probably hard to conduct such an experiement but have there ever been any tests done that compares a persons brain activity who is sleeping to that of someone who's heart has just stopped beating and if they're not revived they'll die?

One last question for anyone who's a doctor or surgeon, when you've revived someone, what do they tell you later afterwards, once they've recovered. Is there anything that's patients tend to recall happening?

I assume it would just be like being knockout?
 
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Most of your queries are easily found through googling...

http://www.ehow.com/facts_6955530_long-human-brain-go-oxygen_.html

Neurons start to die after about 5-6 min. after oxygen denial, which is what would happen if your heart stopped and the blood could no longer carry O2 to your brain.

One last question for anyone who's a doctor or surgeon, when you've revived someone, what do they tell you later afterwards, once they've recovered. Is there anything that's patients tend to recall happening?

I'm not a doctor, but I've heard that some have said something along the lines of "What the %#@& happened!?" Some tend to recall a bright light at the end of a tunnel...However, that conversation is off limits at PF so you're going to have to google that yourself off-site.

As far as your second question...

It's probably hard to conduct such an experiement but have there ever been any tests done that compares a persons brain activity who is sleeping to that of someone who's heart has just stopped beating and if they're not revived they'll die?

I don't think so. I'm sure the ethics committee would think twice before authorizing a study like that. However, if they do, I'd be happy to participate with you if I'm the one doing the sleeping:smile:

Since that probably won't happen, I can tell you that the sleeping brain goes through very specific sleep cycles that are regulated through brainstem biorhythms. Someone's who's just had a heart attack has a brain that is in a trauma state, and the brain rhythms would look nothing like that of a sleep state. I'm pretty sure you're not going to find that answer through googling it, so there you have it.
 
MathJakob said:
From the moment a persons heart stops beating, stop functioning, how long does it take until the brain starts to shut down and how long until it's completely non functional and you're dead beyond the point of revival?

It's probably hard to conduct such an experiement but have there ever been any tests done that compares a persons brain activity who is sleeping to that of someone who's heart has just stopped beating and if they're not revived they'll die?

One last question for anyone who's a doctor or surgeon, when you've revived someone, what do they tell you later afterwards, once they've recovered. Is there anything that's patients tend to recall happening?

I assume it would just be like being knockout?

Once your heart stops (or becomes ineffective at pumping blood, as in ventricular fibrillation), you will pass out within a couple seconds. In CPR classes, one statistic that we use is that for every minute that passes before you start CPR compressions, there is about a 10% increase in mortality rate.
 
MathJakob said:
One last question for anyone who's a doctor or surgeon, when you've revived someone, what do they tell you later afterwards, once they've recovered. Is there anything that's patients tend to recall happening?

Nothing so far in my experience, but I've only been on the chest compression train about 20 times for a code.
 
What blows my mind is the difference between in vivo and in vitro low-oxygen responses. I mean, if I plate a dish of neuron and exposed them to no-oxygen no-glucose (oxygen glucose deprivation, OGD) conditions, it can take a long, long time before they start to die. I mean, we often deprive them of oxygen for hours just to get a 'stress' signal, let alone a 'death' signal.
 

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