Calculate Half Life Values using First Order Kinetics Formula

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The discussion focuses on calculating half-life values using the first-order kinetics formula, specifically T(1/2) = 0.693/k. Participants explored the relationship between half-life values and a factor X, demonstrating that T(1/4) and T(1/8) can be expressed as T(1/2) multiplied by increasing factors of X. The derived formula T(1/2) * Log(100/%) / Log2 = T(100/%) was established for calculating half-lives based on percentage values. Additionally, the equation λP0 = P0e^(-kt) was discussed for determining time t in relation to the decay constant k.

PREREQUISITES
  • Understanding of first-order kinetics
  • Familiarity with logarithmic functions
  • Knowledge of decay constants in chemistry
  • Basic algebra for manipulating equations
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  • Study the application of the first-order kinetics formula in pharmacokinetics
  • Learn about the significance of decay constants in chemical reactions
  • Explore advanced logarithmic equations and their applications
  • Research the differences between percentage and proportion in scientific calculations
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Chemists, pharmacologists, and students studying kinetics or decay processes will benefit from this discussion, particularly those interested in calculating half-lives and understanding the underlying mathematical principles.

Miike012
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Formula consists of calculating half lifes of a first order... T (1/2) = 0.693/k

1. T (1/2)(x) = T (%)

I noticed at various half life values such as T(1/2) , T(1/4) , T(1/8) ... T(%)
That these values are the product of T(1/2) and some Factor "X"... As I stated in formula 1.

-Next I noticed that at every half life each factor of X increased by one
Example: T(1/2) X=1 , T(1/4) X=2, T(1/8) X=3 ...

-Thus if I know the percentage of the half life I can work backwards. Thus determing the Factor X
Example: T(3.125%)

3.125/100 = 1/x ----> x = 32
Thus: T(3.125%) = T(1/32)
At T(1/32) the factor of X is 5... X = 5
And T(1/2)(5) = T(1/32)

-Solving for X
1/32 = 1/2^X ----> 32 = 2^X -----> X = Log32/Log2

*Remeber number 32 is a percentage thus 32 can be substituted for 100/%
and X = Log(100/%)/Log2 ... The base will be a constant equal to 2.

-Finally: Taking both equations and substituting:

1. T(1/2)(X) = T(%)
2. X = Log(100/%)/Log2

Derived formula: T(1/2)*Log(100/%)/Log2 = T(100/%)
 
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Anyone ??
 
Perhaps the reason you have no responses is that your notation is poor and it isn't clear what you are trying to accomplish. If you want to know the value of t for any portion λ of the original amount you just solve

\lambda P_0 =P_0e^{-kt}
for t:
t = -k\ln(\lambda)
If λ = 1/2n this gives (denoting this t as tn)
t_n=-k\ln(\frac 1 {2^n}) =kn\ln(2)= nt_1
where t1 is the time for the first half life.

I guess that's what you are getting at, but I'm not sure what it gets you. And I don't see the point of using percentages instead of proportions.
 

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