Can transgene be made dominant?

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SUMMARY

Transgenes can be made dominant in genetically engineered organisms by inserting the transgene into the germ cells. The dominance of an allele is determined by its biochemical function, with gain-of-function alleles typically exhibiting dominant traits, while loss-of-function alleles are usually recessive. Notably, dominant negative alleles can disrupt the function of the wild type allele, presenting exceptions to the general rule. This understanding is crucial for genetic engineering applications aimed at trait inheritance in offspring.

PREREQUISITES
  • Understanding of genetic engineering principles
  • Knowledge of allele functionality and inheritance patterns
  • Familiarity with germ cell manipulation techniques
  • Basic concepts of dominant and recessive traits
NEXT STEPS
  • Research techniques for germ cell transgene insertion
  • Study the mechanisms of gain-of-function and loss-of-function alleles
  • Explore the implications of dominant negative alleles in genetic engineering
  • Investigate case studies of successful transgene dominance in organisms
USEFUL FOR

Genetic engineers, molecular biologists, and researchers interested in transgenic organisms and inheritance patterns will benefit from this discussion.

anubodh
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Can we make transgene dominant in the genetically engineered organism so that when it mates the offspring would have the same characteristics?
 
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Yes by insertion of the transgene in the germ cell
 
Whether an allele of a gene acts in a dominant or recessive manner depends on the biochemistry of how the allele functions. In general, most loss-of-function alleles act in a recessive manner and most gain-of-function allele act in a dominant manner. Of course, there are many exceptions, such as dominant negative alleles which can interfere with the function of the wild type allele.

Here's a previous PF thread on the topic:
https://www.physicsforums.com/showthread.php?t=568436

And here's a useful article on the subject:
http://genetics.thetech.org/ask/ask227
 

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