Can your body synthesise protein from carbohydrates and nitrogen?

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Discussion Overview

The discussion centers around whether the human body can synthesize proteins from carbohydrates and non-protein nitrogen sources, exploring metabolic pathways and nutritional requirements. It touches on the necessity of dietary protein and the role of essential and non-essential amino acids.

Discussion Character

  • Exploratory, Technical explanation, Debate/contested

Main Points Raised

  • One participant questions if the body can assemble proteins from carbohydrates and nitrogen sources, suggesting a hypothetical scenario without protein intake.
  • Another participant asserts that while cows can synthesize proteins from non-protein sources, humans have evolved to require direct protein intake.
  • A participant notes the importance of sulfur sources for certain amino acids, indicating that not all amino acids can be synthesized from carbohydrates and nitrogen alone.
  • Aychamo discusses the distinction between essential and non-essential amino acids, emphasizing that essential amino acids must be obtained through diet, while non-essential ones can be synthesized from metabolic intermediates.
  • Further clarification is provided regarding the specific amino acids that contain sulfur, highlighting the limitations of relying solely on hydrocarbons and nitrogen for protein synthesis.
  • Participants engage in a light exchange regarding the terminology used to describe amino acids and their components.

Areas of Agreement / Disagreement

Participants generally agree that humans require dietary protein and cannot fully synthesize proteins from carbohydrates and nitrogen alone. However, there is some debate regarding the specifics of amino acid synthesis and the role of dietary sources.

Contextual Notes

The discussion does not resolve the complexities of amino acid biosynthesis and the specific dietary requirements for different amino acids. There are assumptions about metabolic pathways that remain unexamined.

wasteofo2
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If one had no way of eating any protein, but could eat carbohydrates and something which had nitrogen that wasn't a protein, could their body assemble proteins to use, or does that mechanism not exist?
 
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Cows can do that, I believe, but not people. We have evolved to need some protein input.
 
I don't know anything about the metabolism.

But I do know that some amino acids have sulfur groups in them so you would have to have some sulfur source.
 
Aychamo: amino acids have a NH3+ group, thus you need a nitrogen source (like wasteofo2 mentioned).

To answer his question: there are 10 essential amino acids that you need to get through your diet (arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine), the other 10 are non-essential: those can be biosynthesized in adequate amounts.

The essential amino acids are generally the ones with complex structures: aromatic rings and hydrocarbon side-chains. The non-essential ones are those readily synthesized from abundant metabolites, such as intermediates in glycolysis or the citric acid cycle.

Plant proteins are generally deficient in lysine, methionine, or tryptophan, so a vegetarian should eat a varied diet to compensate the deficiency in one source by an excess in another.
 
Monique said:
Aychamo: amino acids have a NH3+ group, thus you need a nitrogen source (like wasteofo2 mentioned).

I know this. I said that some amino acids contain sulfur. That is Methionine and Cysteine. Eating only hydrocarbons and nitrogen wouldn't get you those :)
 
ahh, you had me there :wink: you're right :approve:
 
I guess I should have said sulfur in their R-groups instead of saying they had sulfur groups. :)
 

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