Seems to me it is needed to be able to solve this with elementary concepts.
That C5 might as well not be there – there is no way you can put a charge on it as one end is not connected to anything so there is nowhere a charge can come from to the isolated plate and therefore you cannot maintain a charge on the opposite one.
Then the potential difference is the same across C2, C3 and C4. Charges on each capacitor would therefore be proportional just to their capacitance.. The total charge is the sum of the three. So the sum the equivalent capacitance of the part 234 will be just the sum of the capacitances, which is in fact the general rule for parallel capacitors
Replacing then the three capacitors with one equivalent capacitance, we are left with two capacitors in series. Call the second capacitance C234. System there has a conductively isolated 'inside' part with two plates. The charge on one plate is equal but opposite to that on another, because all the electrons on one must have come from the other. So the two capacitors charges are equal to each other, call this charge Q.
The potential differences in series add up: Vtotal = V1 + V234 = Q1/C1 + Q234/C234. But the charges here, as we previously said, are equal so we just have
Vtotal = Q(1/C1 + 1/C234)
Comparing to the general formula V = Q/C you see that the equivalent capacitance C of this circuit is given by
1/C = (1/C1 + 1/C234)
So that's practically all the calculation, and all the general formula, from first principles.