Integrin-PI3K-Akt signal transduction is well known. Akt signaling has been heavily reviewed and is well known to play a role in metabolism. So why do I have difficulty finding any research that has linked cell adhesion to metabolism? It would make sense. If a cell became cancerous, one way for the body to protect against metastasis would be to shut down the metabolism of that cell if its adhesion started to go haywire in order to prevent it from spreading. I could see profound effects on research here if a clear link between cell adhesion and metabolism were ever made. Anyone know of any papers on this It would also be interesting in a sense that something purely mechanical, like cell adhesion, could control metabolism.