Cell Division of Blood Cells: Facts and Q&A

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Discussion Overview

The discussion revolves around the cell division of blood cells, particularly focusing on the processes involved in white blood cells (WBCs) and their relation to blood cancers. Participants explore the role of bone marrow, stem cells, and the differences between leukemia and lymphoma.

Discussion Character

  • Exploratory
  • Technical explanation
  • Conceptual clarification
  • Debate/contested

Main Points Raised

  • Charles questions whether cell division of blood cells occurs only in the bone marrow, suggesting that WBCs might multiply outside of it in response to infection.
  • Some participants clarify that red blood cells do not divide due to the absence of a nucleus, while white blood cells have different behaviors.
  • There is a discussion about monocytes differentiating into macrophages without division, raising questions about the nature of WBC reproduction.
  • Charles expresses confusion about the role of stem cells if adult WBCs can reproduce independently, questioning the necessity of bone marrow in this process.
  • Participants provide definitions of acute leukemia and chronic leukemia, noting their characteristics and how they differ from lymphomas, which are cancers of the lymph nodes.
  • There is acknowledgment that WBCs can reproduce outside the bone marrow, leading to further inquiry about the significance of bone marrow production.

Areas of Agreement / Disagreement

Participants generally agree on certain biological facts, such as the lack of a nucleus in red blood cells and the ability of WBCs to reproduce outside the bone marrow. However, there remains uncertainty and debate regarding the implications of these points, particularly concerning the role of stem cells and the necessity of bone marrow in WBC production.

Contextual Notes

Participants express varying levels of understanding about the processes involved in blood cell division and the distinctions between different types of blood cancers. Some assumptions about the roles of stem cells and the functions of bone marrow are not fully explored or resolved.

Who May Find This Useful

This discussion may be of interest to individuals studying hematology, oncology, or those seeking to understand the complexities of blood cell biology and related diseases.

Charles
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Hi all,

Before I ask a Q about blood cancers, can I just check - is it right that cell division of blood cells takes place only in the bone marrow (and not in the bloodstream or anywhere else)?

Thanx

Charles
 
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If you're talking about red blood cells, then yes. Red blood cells have no nucleus to divide anyway.

White blood cells are a completely different kettle of fish however.
 
Are they? If you take the monocyte for instance, it doesn't divide anymore but it still differentiates into a macrophage (without division!).
 
Originally posted by Jikx
If you're talking about red blood cells,

OK did I say red blood cells??

White blood cells are a completely different kettle of fish however.

Yeah it's more white cells I'm talking about cos blood cancers are almost always white cells. So I read somewhere that WBCs such as lymphocytes can multiply outside the bone marrow for example in response to infection. So this would mean that not all WBC's come from the bone marrow. So then I am wondering what is the point of stem cells (aka precursor) cells if adult WBC's can reproduce on their own, bypassing the whole bone marrow / stem cell thing?

Also does anyone know about the differences / connections between Leukemia and Lymphoma? I have seen plenty of websites explaining one or the other but not much on comparing and contrasting.

Thanx for any ideas

Charles
 
Charles:

Stem cells are specialized cells that form mainly in the zygote. They can differentiate into any type of cell in the body. ALmost any cell with a nucleous can reproduce on its own without stem cells. Stem cells are of interest now because researchers think that if you place stem cells on a part of the body with damaged cells, the stem cells will grow into new healthy tissue cells.

Acute leukemia is a malignant disease of blood forming tissuescharacterized by uncontrolled production and accumulation of immature leukocytes. Chronic Leukemia is where mature leukocytes accumulate in the bloodstream because they do not die at the end of there normal life span.

Lymphomas are cancers of the lymph nodes, not the blood. Tey are sometimes confused because leukocytes are present in the lymph nodes, and are subsequently affected by lymphomas in a similar way as by leukemia.
 
Originally posted by mark1

Stem cells are specialized cells that form mainly in the zygote. They can differentiate into any type of cell in the body. ALmost any cell with a nucleous can reproduce on its own without stem cells.

Hi all,

Thanx to Mark for reply. IIRC red blood cells and platelets don't have a nucleus but I think that white blood cells do - have I got that right? Also I think that WBC's can reproduce outside the bone marrow bypassing the stem cell thing, for example in response to infection. [?]

Charles
 
You are correct on both things.
 
OK so I was wondering what is the big idea with the bone marrow thing anyway? I mean if WBC's can reproduce on their own what need then is there for them to be produced in the bone marrow[?]


Charles
 

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