This is a great question, and I've spent some time trying to come up with a decent reason. I don't have a complete answer, but I got a good hint from "Conceptual Foundations of Contemporary Relativity Theory", and here it goes:
Let's start with the basic dynamical force equations: Newton's gravitational and Maxwell's electrodynamic equations. Both of these have a form of
F = k/r^2
These equations are important becasue they relate *kinematic* things (distances, accelerations, velocities, charge, time..) to *dynamic* things (forces).
I need to stress that equations of motion are extremely fundamental things, much more fundamental than other types of equations (constitutive relations, disperison relations, etc). Things like Hamilton's equations, or Lagrange's equations, or Shrodinger's equations, Einstein relations, etc... are rooted as equations of motion, even thought they may superficially look more complicated.
Ok- F = k/r^2 is a fundamental equation in physics. It is also known that the 1/r^2 part is due to their being 3 spatial dimensions. So the equations of motion reflect a fundamental property of space.
Now here's the important part: the equation F = k/r^2 is an integral form of Poisson's equation [tex]\nabla^{2}\phi=\rho[/tex], or alternatively Laplace's equation [tex]\nabla^{2}\phi=0[/tex]. Consequently, my book makes the following assertion [pg 179] , and the part I don't fully understand:
"Any physical law must be a partial differential equation containing no derivatives higher than the second, and that the law must be linear in the second derivative."
It goes on to state that "there are no known cases where third (or higher) order differential equations are required in basic laws, nor do we have conceptual resources for interpreting them, but nonlinear equations and combinations of first and second derivatives are known to occur".
Apparently Eddington felt that this was too restrictive, and the reason is "unwarranted bias". However, Schrödinger stated that "The great acheivements of Newton's laws was to concentrate attention on the *second* derivatives- to suggest that *they*- not the first or third or fourth, not any other property of the motion- ought to be accounted for by the environment."
As I said, this is a fascinating topic, and I don't have a good answer for it. However, I think a good explanation is simply that the three-dimensional nature of space leads to physical laws being expressed as second-order differential equations. I would be most interested to hear from anyone else on this.