E=mc² and E=hf serve different purposes in physics, with E=mc² relating to the energy content of mass and E=hf focusing on the energy of photons based on their frequency. E=mc² is applicable to massive particles, while E=hf is specifically for photons, where f represents frequency. The relationship between mass and energy is further expanded in the equation E²=M²c⁴+P²c², which incorporates momentum. For photons, which have zero rest mass, the relevant equation simplifies to E=Pc. Both equations can be correct depending on whether mass is considered as rest mass or relativistic mass.