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Medical Estimating drug dose based on pharmacokinetic data

  1. Sep 24, 2016 #1
    How do clinicians determine the appropriate drug dose based on pharmacokinetic data? I was reading up on a Phase 1 clinical trial study for a chemo drug and was wondering how do clinicians and doctors come up with the drug dose based on these studies. Do they make use of the pharmacokinetic data such as half-life, AUC etc. to determine the optimum drug dose or do they need additional information (apart from the concentration that would produce the required effects)?

    For instance, if a compound exerts it's effect's at 0.3uM in vitro, what parameters are needed to determine the drug dose such that on ingesting that dose the same effects are observed in vivo? Thanks in advance for your replies!
  2. jcsd
  3. Sep 24, 2016 #2


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