Evaluation of an experiment: PET scans of a small source along the x-axis

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Homework Help Overview

The discussion revolves around the evaluation of a PET scan experiment, focusing on the analysis of coincidence count rates measured along the x-axis. The original poster describes their methodology for error calculation and seeks guidance on plotting data and fitting a Gaussian curve to the results.

Discussion Character

  • Exploratory, Conceptual clarification, Mathematical reasoning, Problem interpretation

Approaches and Questions Raised

  • The original poster attempts to calculate errors in their measurements and fit a Gaussian curve to the data, questioning the accuracy of their FWHM calculation and how to determine its error. Participants suggest considering the background counts in the fitting process and propose methods for estimating this background.

Discussion Status

Participants are actively engaging with the original poster's queries, providing suggestions for estimating background counts and discussing the implications of accidental counts on the Gaussian fit. There is a collaborative exploration of methods to improve the analysis without a clear consensus yet on the best approach.

Contextual Notes

The original poster mentions an assumed error of 1 mm in their measurements and uses Poisson statistics for error calculations. The discussion includes considerations of accidental counts affecting the Gaussian distribution and the need for careful background estimation.

Lambda96
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Homework Statement
Evaluation of an experiment
Relevant Equations
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Hi,


I did a PET scan and positioned a sample almost in the center of a moving carriage, taking measurements along the x-axis and measuring the counts. Each measurement took 60 seconds, and I took a total of 27 measurements. Here are my results

Tabelle.png


As the display was in mm, I always assumed an error of 1 mm. For the error calculation of the counts, I used Poisson, i.e. ##\Delta count= \sqrt{n}## and for the errors of the counts per seconds I calculated as follows: ##\Delta## counts per second = ##\frac{\Delta count}{t}##


Now I have to do the following

Plot the position of the trolley (error discussion!) against the measured coincidence count rate graphically (with x-y errors). Fit the peak with a Gaussian curve (with x-y errors) and determine the FWHM. How does this result serve as an error for further measurements?

For the plots I used Origin and for the plot of the counts per second plus the error in x and y I had no problem and got the following:




Bildschirmfoto 2024-06-24 um 20.25.41.png

Unfortunately, I'm not sure if I did the plot regarding the peak with the Gauss curve correctly and that I calculated the FWHM correctly, for FWHM I have used the formula ##FWHM=2 \sqrt{2 \ln{2}} \sigma##, where ##\sigma=1.4215## which means that ##FWHM=3.35##. But how do I calculate the error of the FWHM?

Here is the plot

Bildschirmfoto 2024-06-24 um 20.34.50.png
 
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Let me begin by saying that I believe this experiment was meant to determine a point response function and thus the spatial resolution of your scanner assuming you used a point source. It would also seem that there were a substantial number of accidental counts meaning that the distribution was not a pure Gaussian but a Gaussian sitting on a background of some sort. I think the FWHM is significantly correlated with the accidental count background. I would try to estimate the form of the background and include it in the fit at least to see its effect on the value of σ. If you used a nonlinear fitting routine it should estimate the uncertainty in σ of the Gaussian from which you can determine the FWHM uncertainly.
 
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Likes   Reactions: DeBangis21, Lambda96 and berkeman
Thank you very much for your help 👍

How exactly can I estimate the background with the help of the measured data?
 
My approach is to start with the simplest functional form that makes sense Usually a straight line. bg = ax +b and see if that gives a reasonable χ2. If the χ2 is still unreasonable add a cx2 term and repeat. Don't try to overfit it. Backgrounds usually are structureless, with no peaks or fissures that might have too much effect unless you have a valid reason to use a more complex form. You can look at residuals to see where your model is failing. It might provide some guidance as to what to use.
 

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