The discussion centers on identifying examples of Lie groups that cannot be represented as matrix groups. Participants mention the adjoint representation and its implications for matrix group representation, emphasizing the need for a faithful representation. The metaplectic group is highlighted as a specific example, noted for being a double cover of the symplectic group and not simply connected. There is clarification on the distinction between the metaplectic group and its universal cover, with participants correcting misunderstandings about their properties. The conversation underscores the complexity of representing certain Lie groups in matrix form.